{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:30:01Z","timestamp":1773419401855,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030684","name":"Maruho","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We often experience sustained improvement, even after discontinuation of treatment in psoriasis lesions treated with topical vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (VD\n                    <jats:sub>3<\/jats:sub>\n                    ) or the combination of topical corticosteroids and VD\n                    <jats:sub>3<\/jats:sub>\n                    . However, the underlying mechanisms of these sustained effects remain unclear. We explored mechanisms for the sustained effects of maxacalcitol (MCT) and combined MCT\/betamethasone butyrate propionate (BBP) ointments using a murine psoriasiform dermatitis model induced by imiquimod (IMQ). IMQ was applied once daily to the shaved backs of mice for 6\u2009days to induce psoriasiform dermatitis. MCT, BBP, combined MCT\/BBP ointment, or their vehicles were treated for 3\u2009days prior to IMQ application. IMQ was reapplied after 1, 2, or 3\u2009weeks from the first IMQ application to investigate the sustained effects of their ointments. In the first application of IMQ, the administration of MCT, BBP, or MCT\/BBP ointment improved clinical and pathological manifestations and reduced Th17\u2010related cytokines. Treatment with MCT or MCT\/BBP showed an increase in IL\u201010 mRNA expression and a higher count of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells within the skin, but not in those with BBP. The induction of IL\u201010 by MCT and MCT\/BBP persisted until reapplication of IMQ 2\u2009weeks later, although their effects diminished 3\u2009weeks later. The reduction in Th17\u2010related cytokines was maintained up to 3\u2009weeks later in MCT\/BBP, whereas it was not observed 2\u2009weeks later in MCT. In conclusion, MCT and MCT\/BBP showed long\u2010term effects by induction of regulatory T cells and IL\u201010. Additionally, MCT\/BBP downregulated Th17\u2010related cytokines, which could contribute to the sustained improvement after discontinuation observed in clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70031","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T07:44:41Z","timestamp":1761378281000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Maxacalcitol\/Betamethasone Butyrate Propionate Ointment Possesses Long\u2010Term Sustained Effects of Inducing Regulatory T Cells and Downregulating the Th17 Response, Even After Discontinuation of Its Application in Imiquimod\u2010Induced Psoriasiform Dermatitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Teruo","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-4982","authenticated-orcid":false,"given":"Masahiro","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Uratsuji","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd.  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