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Infliximab is often used for steroid\u2010refractory cases, yet its effect on tumor control remains uncertain. We describe three advanced melanoma patients who developed grade 3\u20134 colitis after nivolumab plus ipilimumab and were treated with infliximab. Although gastrointestinal symptoms improved, all showed rapid disease progression and died within 3\u20139\u2009months. 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