{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:29:24Z","timestamp":1773419364985,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Minocycline, a semisynthetic tetracycline, is widely used to treat inflammatory skin diseases such as acne and rosacea. Despite its favorable safety profile, it may cause various adverse effects, including hypersensitivity reactions. We describe the case of a 20\u2010year\u2010old male who developed delayed\u2010onset symptomatic dermographism following oral minocycline treatment (100\u2009mg\/day) for acne. One week after starting treatment, the patient developed pruritic, evanescent, linear wheal\u2010like lesions at multiple sites, without angioedema or systemic symptoms. Lesions resolved spontaneously within two weeks of drug withdrawal. An oral challenge test with escalating doses of minocycline, up to a cumulative total of 100\u2009mg initially, showed tolerance; however, symptoms recurred after nine consecutive days at the therapeutic dose, confirming causality. Symptoms resolved following drug discontinuation and a 2\u2010day course of oral cetirizine. To evaluate cross\u2010reactivity, prick and intradermal tests with doxycycline were negative, and a 10\u2010day oral doxycycline challenge was uneventful, indicating no cross\u2010reactivity. Symptomatic dermographism is the most common form of chronic inducible urticaria, but its association with minocycline is rare. The underlying immunopathogenesis remains unclear, potentially involving mast cell activation or superantigen\u2010like effects. This case underscores the importance of prolonged drug rechallenge in identifying rare delayed adverse reactions such as minocycline\u2010induced late\u2010onset symptomatic dermographism and supports the safe use of doxycycline as an alternative.<\/jats:p>","DOI":"10.1111\/1346-8138.70046","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:20:30Z","timestamp":1762492830000},"page":"145-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Minocycline\u2010Induced Delayed Dermographism With Tolerance to Doxycycline"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0981-4545","authenticated-orcid":false,"given":"Mar\u00eda Nerea","family":"Otero\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-9928","authenticated-orcid":false,"given":"Francisco Javier","family":"Mu\u00f1oz\u2010Bellido","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"},{"name":"Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico Universidad de Salamanca  Salamanca Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientadas a Resultados en Salud (RICORS RD21\/0002\/0054), Red de Enfermedades Inflamatorias (REI), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-004X","authenticated-orcid":false,"given":"Elena","family":"Laffond\u2010Yges","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"},{"name":"Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico Universidad de Salamanca  Salamanca Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientadas a Resultados en Salud (RICORS RD21\/0002\/0054), Red de Enfermedades Inflamatorias (REI), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-0854","authenticated-orcid":false,"given":"Milagros","family":"L\u00e1zaro\u2010Sastre","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8245-4377","authenticated-orcid":false,"given":"Adelaida","family":"Cabrera\u2010N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8749-3304","authenticated-orcid":false,"given":"Elena","family":"Mazoteras\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7052-5810","authenticated-orcid":false,"given":"Egle\u00e9 Elena","family":"Mu\u00f1oz\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-5513","authenticated-orcid":false,"given":"Ignacio","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL)  Salamanca Spain"},{"name":"Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico Universidad de Salamanca  Salamanca Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientadas a Resultados en Salud (RICORS RD21\/0002\/0054), Red de Enfermedades Inflamatorias (REI), Instituto de Salud Carlos III  Madrid 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