{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:54Z","timestamp":1787013594158,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>SDR9C7<\/jats:italic>\n                    \u2010nonsyndromic epidermal differentiation disorder (nEDD) is a form of ceramide synthesis disorder that is known to confer susceptibility to dermatophytosis. Recurrent widespread tinea corporis developed in a\n                    <jats:italic>SDR9C7<\/jats:italic>\n                    \u2010nEDD patient with homozygosity for the Japanese founder variant (c.826C&gt;T, p.Arg276Cys) during apremilast treatment to improve ectropion. Ceramide analysis of the stratum corneum revealed decreased protein\u2010bound ceramides, indicating skin barrier dysfunction. Based on previous studies of decreased\n                    <jats:italic>Irf4<\/jats:italic>\n                    mRNA in\n                    <jats:italic>Sdr9c7<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, IRF4 transcription factor\u2010dependent IL\u201017 production, and the importance of IL\u201017A\/F in mucocutaneous immunity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , we examined the expression of each molecule using immunofluorescence and found for the first time decreased IRF4 and IL17\u2010A\/C\/F (which were further decreased by apremilast treatment) in\n                    <jats:italic>SDR9C7<\/jats:italic>\n                    \u2010nEDD epidermis. Although further studies are needed to clarify an evaluation of cytokine profiles in\n                    <jats:italic>SDR9C7<\/jats:italic>\n                    \u2010nEDD, which may have immune profiles different from the previously reported IL\u201017\u2010dominant immune profiles in the major forms of ichthyosis, these findings might have contributed to susceptibility to dermatophytosis in this patient, and it is suggested that the use of apremilast should be avoided in\n                    <jats:italic>SDR9C7<\/jats:italic>\n                    \u2010nEDD.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70048","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:26:42Z","timestamp":1762932402000},"page":"149-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Susceptibility to Dermatophytosis in\n                    <scp>\n                      <i>SDR9C7<\/i>\n                    <\/scp>\n                    \u2010Nonsyndromic Epidermal Differentiation Disorder: Observation of Cutaneous Inflammation Involving\n                    <scp>IRF4<\/scp>\n                    and\n                    <scp>IL<\/scp>\n                    \u201017"],"prefix":"10.1111","volume":"53","author":[{"given":"Makiko","family":"Tajiri","sequence":"first","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-2875","authenticated-orcid":false,"given":"Takuya","family":"Takeichi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Nagoya University Institute for Advanced Research  Nagoya 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School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-3515","authenticated-orcid":false,"given":"Kana","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-032X","authenticated-orcid":false,"given":"Hiroshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Fukuoka Japan"},{"name":"Kurume University Institute of Cutaneous Cell Biology  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-6611","authenticated-orcid":false,"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  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