{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:36:38Z","timestamp":1777948598698,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although the histopathological features of BP are well documented, basal cell necrosis (BCN) in the blister roof has not been systematically studied. We retrospectively reviewed the clinicopathological findings of BP cases to assess the prevalence and extent of BCN and to explore its underlying mechanisms. Forty\u2010one BP cases diagnosed between 2011 and 2017 were analyzed, with 35 cases of other subepidermal blistering disorders serving as controls. BCN was identified along the base of the blister roof in 92.7% (38\/41) of BP cases, typically in a confluent linear array, whereas only 8.6% (3\/35) of control cases showed BCN. The extent of BCN correlated strongly with eosinophil density in the blister cavity but not with the serum levels of anti\u2010BP180 or anti\u2010BP230 antibodies. Immunohistochemical study showed that BCN in BP was mediated by caspase\u20103 (CASP3)\u2010dependent apoptosis and\/or receptor\u2010interacting protein kinase\u20103 (RIP3)\u2010dependent necroptosis pathways. Our study indicated that BCN, mediated via CASP3\u2010dependent apoptosis and\/or RIP3\u2010dependent necroptosis pathways, is a very common histological feature of BP and may serve as a useful diagnostic clue.<\/jats:p>","DOI":"10.1111\/1346-8138.70053","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T11:49:36Z","timestamp":1763380176000},"page":"245-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting the Pathology of Bullous Pemphigoid: Basal Cell Necrosis as a Diagnostic Clue and Its Pathogenic Role"],"prefix":"10.1111","volume":"53","author":[{"given":"Hsuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-4615","authenticated-orcid":false,"given":"Ping\u2010Chen","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Hao","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-5870","authenticated-orcid":false,"given":"Hsin\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Rung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-4533","authenticated-orcid":false,"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"International Research Center of Wound Repair and Regeneration (iWRR) National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-7357","authenticated-orcid":false,"given":"Julia Yu\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"International Research Center of Wound Repair and Regeneration (iWRR) National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00595-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16654"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.11.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15114"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2719"},{"key":"e_1_2_9_7_1","volume-title":"McKee's Pathology of the Skin","author":"Eduardo Calonje T. 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