{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:29:49Z","timestamp":1773419389723,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K19589"],"award-info":[{"award-number":["25K19589"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25HP8021"],"award-info":[{"award-number":["25HP8021"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Systemic sclerosis is an autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. Anti\u2010SS\u2010A antibodies (anti\u2010SSA) have been reported to confer severe clinical manifestations in some Western and Japanese cohorts. We aimed to determine whether anti\u2010SSA seropositivity affects clinical outcomes in Japanese patients. We retrospectively analyzed 307 Japanese patients with systemic sclerosis who underwent initial evaluation between January 2011 and March 2020 in our clinic. \u201cIsolated\u201d anti\u2010SSA seropositivity was defined as positivity for anti\u2010SSA in the absence of anti\u2010topoisomerase I, anti\u2010centromere, anti\u2010RNA polymerase III, and anti\u2010U1 ribonucleoprotein antibodies. Overall survival was defined as time to all\u2010cause mortality, and progression\u2010free survival was defined as time to disease progression necessitating intensified therapy. Cox proportional hazards models were employed to estimate hazard ratios and 95% confidence intervals. For patients with \u201cisolated\u201d anti\u2010SSA seropositivity, further investigation for SSc\u2010related autoantibodies was conducted utilizing Autoantibody Array Assay (A\u2010Cube). Anti\u2010SSA were detected in 31.3% of patients. Although anti\u2010SSA seropositivity overall correlated with interstitial lung disease, it was not independently associated with overall survival or progression\u2010free survival. In contrast, \u201cisolated\u201d anti\u2010SSA seropositivity emerged as an independent risk factor for both shorter overall survival (hazard ratio 21.7, 95% confidence interval 5.57\u201384.8) and progression\u2010free survival (hazard ratio 4.18, 95% confidence interval 1.05\u201316.7). Expanded serologic testing revealed additional autoantibodies implicated in severe SSc phenotypes. These findings underscore the importance of routinely assessing anti\u2010SSA and highlight the need for autoantibody screening in depth in this subpopulation.<\/jats:p>","DOI":"10.1111\/1346-8138.70055","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:29:35Z","timestamp":1763800175000},"page":"41-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Anti\u2010\n                    <scp>SS<\/scp>\n                    \u2010A Antibody Seropositivity as a Poor Prognostic Factor in Systemic Sclerosis: Insights From a Cohort of 307 Cases"],"prefix":"10.1111","volume":"53","author":[{"given":"Nana","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-8047","authenticated-orcid":false,"given":"Kazuki M.","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-0663","authenticated-orcid":false,"given":"Hirohito","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayakazu","family":"Sumida","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine  Tokyo Japan"},{"name":"Scleroderma Center, The University of Tokyo Hospital  Tokyo Japan"},{"name":"SLE Center The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13238"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000959"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08946-w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00762.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.05.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3763"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3495"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03325-6"},{"issue":"11","key":"e_1_2_10_12_1","first-page":"1747","article-title":"2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology\/European League Against Rheumatism Collaborative Initiative","volume":"72","author":"Van Den Hoogen F.","year":"2013","journal-title":"Arthritis & Rheumatism"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1255540"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"202","article-title":"Scleroderma (Systemic Sclerosis): Classification, Subsets and Pathogenesis","volume":"15","author":"LeRoy E. 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M.Matsuda S.Ebata K.Iwadoh et\u00a0al. \u201cDeciphering Autoantibody Landscape of Systemic Sclerosis Through Systems\u2010Based Approach: Insights From a B\u2010Cell Depletion Clinical Trial \u201dmedRxiv. 2024 https:\/\/doi.org\/10.1101\/2024.07.30.24311212.","DOI":"10.1101\/2024.07.30.24311212"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.241786"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00797-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102774"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2023-002076"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12322"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2021.1887927"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6756"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138416"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01637-z"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:16:25Z","timestamp":1773411385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1346-8138.70055"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70055","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}