{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:36:30Z","timestamp":1777948590848,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010793","name":"Pfizer Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitiligo is a disorder characterized by depigmentation of the skin and is known to impact patients' health\u2010related quality of life (HRQoL). In Japan, HRQoL studies on vitiligo remain limited in size and scope, and factors contributing to impaired HRQoL, as well as the psychological burden, have not been adequately evaluated. This study aimed to assess HRQoL and symptoms of anxiety and depression in patients with vitiligo in Japan. A web\u2010based survey was completed by 271 patients with vitiligo aged 18 to 79\u2009years. The survey included the 12\u2010item Short Form Health Survey version 2 (SF\u201012v2) and the Dermatology Life Quality Index (DLQI) to assess HRQoL, as well as the Hospital Anxiety and Depression Scale (HADS). The role\/social component summary score (mean\u2009\u00b1\u2009standard deviation) of the SF\u201012v2 in vitiligo patients was 45.8\u2009\u00b1\u200914.5, which was lower than the Japanese population norm (national standard values for Japanese). Based on the DLQI, which is specific to dermatologic diseases, 62.7% of patients reported at least a small effect on their daily lives. HADS anxiety and depression scores showed that 38.0% and 40.3% of patients, respectively, were classified as doubtful or definite cases. Subgroup analyses revealed that higher DLQI and HADS scores were associated with sex, age, disease duration, affected body surface area (BSA), and history of relapse. Notably, nonlinear associations in these measures were observed for disease duration and affected BSA, with the highest scores seen in patients with an intermediate range of disease duration and affected BSA. These findings underscore the need for timely and sustained treatment strategies to control symptoms, reduce psychological distress, and prevent relapse, which may help not only improve clinical outcomes but also maintain long\u2010term HRQoL in individuals with vitiligo.<\/jats:p>","DOI":"10.1111\/1346-8138.70059","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:03:19Z","timestamp":1764230599000},"page":"200-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health\u2010Related Quality of Life and Psychological Burden of Patients With Vitiligo in Japan"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-6496","authenticated-orcid":false,"given":"Naoki","family":"Oiso","sequence":"first","affiliation":[{"name":"Department of Dermatology Kindai University Nara Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-4884","authenticated-orcid":false,"given":"Yasutaka","family":"Mizoro","sequence":"additional","affiliation":[{"name":"Specialty Care Medical Affairs Pfizer Japan Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-5142","authenticated-orcid":false,"given":"Kazumasa","family":"Kamei","sequence":"additional","affiliation":[{"name":"Japan Access and Value Pfizer Japan Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0649-7148","authenticated-orcid":false,"given":"Kenichi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Specialty Care Medical Affairs Pfizer Japan Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-1807","authenticated-orcid":false,"given":"Masato","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Specialty Care Medical Affairs Pfizer Japan Inc.  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