{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:25:09Z","timestamp":1768040709765,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006453","name":"Taisho Toyama Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Telogen effluvium (TE) refers to a transient hair loss condition due to the global and premature transition of scalp hair follicles from the anagen to the telogen phase of the hair cycle leading to excessive hair loss, which is triggered by a variety of physical\/emotional stress, including severe infectious diseases. Because of its self\u2010healing nature, attempts to develop remedies for TE have rarely been conducted; still the demand for TE treatment exists as the condition can significantly impair the quality of life of affected individuals. This study aims to establish a mouse model of TE induced by lipopolysaccharide (LPS) and evaluate the therapeutic effects of topical minoxidil (tMXD), an established hair growth\u2010promoting medication. Mice had their dorsal hairs plucked to induce anagen transition and were administered LPS. LPS elicited a condition mimicking a cytokine storm with increases in interleukin\u20106 levels and neutrophil counts. Accelerated transition of hair follicles into telogen was observed in LPS\u2010treated mice. Intriguingly, tMXD accelerated hair regrowth in LPS\u2010treated mice, resulting in earlier achievement of complete hair regrowth compared to controls. In aggregate, a previously unreported TE mouse model is established, and its use supports the ameliorative effect of tMXD on TE.<\/jats:p>","DOI":"10.1111\/1346-8138.70062","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T06:39:12Z","timestamp":1763361552000},"page":"1864-1868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Minoxidil Promotes Hair Growth in a Mouse Model of Telogen Effluvium Induced by Lipopolysaccharide"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6987-536X","authenticated-orcid":false,"given":"Yuji","family":"Tani","sequence":"first","affiliation":[{"name":"Pharmacology, Self\u2010Medication Research Center, Research Headquarters Taisho Pharmaceutical Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Makihara","sequence":"additional","affiliation":[{"name":"Pharmacology, Self\u2010Medication Research Center, Research Headquarters Taisho Pharmaceutical Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Morito","sequence":"additional","affiliation":[{"name":"Pharmacology, Self\u2010Medication Research Center, Research Headquarters Taisho Pharmaceutical Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5717","authenticated-orcid":false,"given":"Manabu","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.01.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16475"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13021026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1945"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.119.167"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00390.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01377.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680240096017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.17.2529"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30997-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03784.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14470"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00028.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00673.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:34:40Z","timestamp":1768026880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1346-8138.70062"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70062","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,16]]},"assertion":[{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}