{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:26:26Z","timestamp":1782534386623,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI\u2010114\u201028"],"award-info":[{"award-number":["CI\u2010114\u201028"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115B\u2010024"],"award-info":[{"award-number":["V115B\u2010024"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prurigo nodularis (PN) is a chronic inflammatory skin disorder associated with various systemic disorders. However, its potential link to increased malignancy risk remains unclear. We conducted a retrospective cohort study using the US Collaborative Network in the TriNetX database, encompassing data from January 1, 2016 to January 1, 2022. Adults diagnosed with PN (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910\u2009941) were matched 1:1 with controls without PN (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910\u2009941) based on demographics, comorbidities, and medication use. The primary outcome was the hazard ratio (HR) for malignancy occurring between 3\u2009months and 5\u2009years after the index date. The HRs and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models. Patients with PN exhibited a significantly increased risk of developing malignancies compared with the controls (HR 2.10; 95% CI 1.81\u20132.43). Notably, higher risks were observed for cutaneous squamous cell carcinoma (HR 4.24; 95% CI 2.69\u20136.69), basal cell carcinoma (HR 2.49; 95% CI 1.68\u20133.69), hematopoietic cancers (HR 1.97; 95% CI 1.26\u20133.06), gastrointestinal cancers (HR 1.87; 95% CI 1.24\u20132.81), respiratory system cancers (HR 1.86; 95% CI 1.23\u20132.82), and female genital cancers (HR 2.77; 95% CI 1.29\u20135.95). In conclusion, PN is associated with a significantly elevated risk of malignancy, particularly cutaneous cancers. These preliminary findings underscore the necessity for heightened clinical vigilance. Further prospective studies are needed to confirm this association, elucidate the underlying mechanisms, and evaluate the potential benefits of routine cancer screening in this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70112","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:02:10Z","timestamp":1765591330000},"page":"281-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Prurigo Nodularis and Malignancy: A Real\u2010World Multicenter Retrospective Cohort Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-5787","authenticated-orcid":false,"given":"Yu\u2010Hsiang","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei 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Medical Education Shin Kong Wu Huo\u2010Shih Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Dermatology National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cian\u2010Hao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology Far Eastern Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-5083","authenticated-orcid":false,"given":"Sheng\u2010Hsiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei 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