{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:15:53Z","timestamp":1774682153735,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parenteral nutrition (PN) is a critical intervention for patients unable to tolerate enteral nutrition. Commercially available multi\u2010chamber PN formulations are widely used due to their safety and cost\u2010effectiveness. However, hypersensitivity reactions (HSRs), including anaphylaxis, must be carefully considered. Here, we report on a 38\u2010year\u2010old female with intestinal obstruction due to peritoneal dissemination of colon cancer who developed anaphylaxis to a multi\u2010chamber PN formulation. Skin prick and intradermal tests identified the specific chamber as the causative component. PN\u2010related HSRs are rare, but can severely impact nutritional management. Identifying specific allergens is crucial for avoiding unnecessary PN discontinuation. This case highlights the importance of incorporating allergy testing into the management of multi\u2010chamber PN, allowing safe continuation of nutrition and guiding individualized strategies for patients at risk of hypersensitivity.<\/jats:p>","DOI":"10.1111\/1346-8138.70127","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T08:06:29Z","timestamp":1766822789000},"page":"514-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anaphylaxis to Total Parenteral Nutrition Components Diagnosed by Skin Tests"],"prefix":"10.1111","volume":"53","author":[{"given":"Tadashi","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5890-3606","authenticated-orcid":false,"given":"Toshihiko","family":"Komai","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Yotsuyanagi","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo 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