{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:16:02Z","timestamp":1774682162552,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a case of acute myocarditis in a 25\u2010year\u2010old man with refractory generalized pustular psoriasis (GPP) following treatment with spesolimab, an anti\u2013IL\u201036 receptor monoclonal antibody. Cardiac magnetic resonance fulfilled the Lake\u2010Louise criteria for myocarditis, and genetic testing revealed a heterozygous pathogenic\/likely pathogenic\n                    <jats:italic>MYH7<\/jats:italic>\n                    variant, suggesting a possible gene\u2013environment\u2013drug interaction. The patient was managed with supportive care and presented no complications. In outpatient evaluation, the patient has remained asymptomatic with no further hospital admissions. This case underscores the need for vigilance regarding cardiac adverse events during IL\u201036 blockade and highlights the potential role of genetic predisposition in modulating susceptibility to myocardial injury.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70135","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:55:46Z","timestamp":1767614146000},"page":"524-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Myocarditis During a Generalized Pustular Psoriasis Flare: A Possible Pharmacogenetic Interaction in the Setting of Severe Systemic Inflammation?"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6758-0772","authenticated-orcid":false,"given":"Jo\u00e3o Mendes","family":"Cravo","sequence":"first","affiliation":[{"name":"Department of Cardiology, ULS Santa Maria, CAML, CCUL@RISE, Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-7889","authenticated-orcid":false,"given":"Joana","family":"Vieitez\u2010Frade","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de Santa Maria Unidade Local de Sa\u00fade Santa Maria  Lisbon Portugal"},{"name":"Dermatology University Clinic, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0669-5366","authenticated-orcid":false,"given":"Gustavo","family":"Almeida\u2010Silva","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de Santa Maria Unidade Local de Sa\u00fade Santa Maria  Lisbon Portugal"},{"name":"Dermatology University Clinic, Faculdade de Medicina Universidade de Lisboa  Lisbon 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