{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:22:22Z","timestamp":1788985342781,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Real\u2010world data are limited on 2\u2009year effectiveness of tyrosine kinase 2 inhibitor deucravacitinib for psoriasis, especially that stratified by body mass index (BMI) or age. This study is aimed to evaluate 104\u2009week effectiveness of deucravacitinib in patients with psoriasis, stratified by BMI (&lt;\u200925 versus \u2265\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) or age (&lt;\u200965 versus \u2265\u200965\u2009years). We included 127 patients with moderate\u2010to\u2010severe psoriasis who received deucravacitinib 6\u2009mg once daily. Psoriasis area and severity index (PASI) decreased throughout 104\u2009weeks in whole patients. In between\u2010group comparisons, mean percent reduction of PASI did not significantly differ at any time point in either BMI or age stratification. The amount of decreasing PASI and achievement rates of PASI 75, 90, and absolute PASI \u2264\u20092 through week 16 to 68 were slightly higher in BMI\u2009&lt;\u200925 than in BMI \u2265\u200925, thereafter inverted order. The achievement rates of PASI 100 or absolute PASI \u2264\u20091 were higher in BMI\u2009&lt;\u200925 throughout 104\u2009weeks; week 104 PASI 100 or absolute PASI \u2264\u20091 rates were 16.7% or 54.2% in BMI\u2009&lt;\u200925 while 0% or 40% in BMI \u2265\u200925, respectively. Percent reduction of PASI and achievement rates of PASI 75 and 90 were slightly higher in age\u2009\u2265\u200965\u2009years than in age\u2009&lt;\u200965\u2009years by week 52, thereafter inverted order. Week 104 achievement rates of PASI 100 or absolute PASI \u2264\u20091 were 28.6% or 57.1% in age\u2009&lt;\u200965\u2009years while 0% or 46.7% in age\u2009\u2265\u200965\u2009years, respectively. Deucravacitinib reduced PASI throughout 104\u2009weeks in whole patients. Patients with BMI\u2009&lt;\u200925 or age\u2009\u2265\u200965\u2009years might show slightly higher response to deucravacitinib at early time points around 1 year compared to slightly higher response at later time points in those with BMI \u2265\u200925 or age\u2009&lt;\u200965\u2009years. Patients with BMI \u2265\u200925 or age\u2009\u2265\u200965\u2009years might have difficulty in keeping PASI 100 through week 104.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70137","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:05:06Z","timestamp":1767614706000},"page":"496-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Two\u2010Year Real\u2010World Effectiveness of Deucravacitinib 6\u2009mg in Psoriasis: A Single\u2010Center Analysis Stratified by Body Mass Index or Age in a Japanese Cohort"],"prefix":"10.1111","volume":"53","author":[{"given":"Yuriko","family":"Okabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo 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