{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:47:53Z","timestamp":1792248473829,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020377","name":"Maruho Takagi Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016730","name":"Torii Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tralokinumab, an anti\u2010IL\u201013 antibody, is effective for atopic dermatitis (AD); however, its long\u2010term (&gt;\u20091\u2009year) effectiveness specific to each anatomical site is unknown in real\u2010world settings. To evaluate 72\u2010week effectiveness of tralokinumab on different anatomical sites in AD, we studied 208 patients with moderate\u2010to\u2010severe AD treated with tralokinumab for 72\u2009weeks. Eczema area and severity index (EASI) scores were analyzed on four anatomical sites (head\/neck, trunk, upper limbs, and lower limbs). Tralokinumab consistently reduced EASI on all anatomical sites. The achievement rates of EASI 75 and 100 on each site gradually increased from Week 4 to Week 72, and those on lower limbs appeared higher compared to the other sites. The percent reductions of EASI throughout 72\u2009weeks appeared slightly lower on head and neck compared to the other sites. Week 72 achievement rate of EASI 75 on head\/neck, trunk, upper limbs, or lower limbs was 80.4%, 80%, 80.3%, or 86.7%, while that of EASI 100 was 37.3%, 25.0%, 27.4%, and 40.0%, respectively. Tralokinumab reduced EASI scores through 72\u2009weeks across different anatomical sites in AD patients. The achievement rates of EASI 75 and 100 appeared slightly higher on lower limbs compared to the other sites.<\/jats:p>","DOI":"10.1111\/1346-8138.70138","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:53:54Z","timestamp":1767614034000},"page":"454-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010Term, Site\u2010Specific Effectiveness of Tralokinumab in Atopic Dermatitis: A 72\u2010Week Real\u2010World Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Mizuki","family":"Shiba","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-9596","authenticated-orcid":false,"given":"Teppei","family":"Hagino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-2427","authenticated-orcid":false,"given":"Akihiko","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5914-3244","authenticated-orcid":false,"given":"Eita","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujimoto Dermatology Clinic  Funabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-0669","authenticated-orcid":false,"given":"Sei\u2010ichiro","family":"Motegi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-2312","authenticated-orcid":false,"given":"Naoko","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.646"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16549"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.08.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)31286\u20101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2023.100195"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2021.10.004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13954"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499431"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13160"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2020.1858802"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.018"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v101.369"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.12.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2021\u20101\u20107"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt\u20102022\u20100307"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15811"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19574"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19573"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.0627"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010022\u201000702\u20102"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20832"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad038"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0030"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0084"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0261"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2024.4750"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0323"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19382"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.09.034"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0538"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.17544"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.24.127"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2025.0146"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.05.029"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16108"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0515"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/17103568251367787"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/17103568251361929"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0460"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/17103568251388043"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/17103568251380867"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16950"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16763"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/17103568251361920"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:18:14Z","timestamp":1774678694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/1346-8138.70138"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70138","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}