{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:08:14Z","timestamp":1776100094588,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vascular anomalies are classified according to the ISSVA classification into vascular tumors with endothelial proliferation and vascular malformations without proliferation. Infantile hemangioma is a vascular tumor that is diagnosed by GLUT\u20101 immunoreactivity. GLUT\u20101 positivity is reportedly sometimes observed in angiosarcoma, but the clinical significance remains unclear. Here, immunohistochemistry was performed on tissue samples from patients with angiosarcoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), pyogenic granuloma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), and senile hemangioma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), with infantile hemangioma serving as a positive control. GLUT\u20101 expression was detected in the cytoplasm and\/or cell membrane of tumor cells in all cases of angiosarcoma (100%), as well as in the cytoplasm of some cases of pyogenic granuloma (44.4%) and senile hemangioma (40%). Double immunofluorescent staining for GLUT\u20101 and CD34 revealed co\u2010expression in tumor endothelial cells of angiosarcoma. Clinically, cases of angiosarcoma with strong membranous GLUT\u20101 expression tended to be associated with tumor progression, while those with weak or mild cytoplasmic expression showed a better response to treatment. These findings suggest that GLUT\u20101 may serve as a useful marker of tumor progression for angiosarcoma, and as a potential therapeutic target in vascular tumors.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70147","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:59:57Z","timestamp":1768381197000},"page":"632-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Pathological Significance of\n                    <scp>GLUT<\/scp>\n                    \u20101 Expression in Angiosarcoma and Other Vascular Tumors"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-3848","authenticated-orcid":false,"given":"Aya","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Kunimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7116-211X","authenticated-orcid":false,"given":"Mamiko","family":"Masuzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kitasato University School of Medicine Sagamihara, Kanagawa  Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Masuzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kitasato University School of Medicine Sagamihara, Kanagawa  Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Amoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kitasato University School of Medicine Sagamihara, Kanagawa  Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Jinnin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.15189"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.04.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010018\u20100531\u20103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014334"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16861"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066\u2010006\u20101525\u20109"},{"issue":"15","key":"e_1_2_8_10_1","first-page":"5731","article-title":"HIF\u20101alpha\u2010Mediated Up\u2010Regulation of Vascular Endothelial Growth Factor, Independent of Basic Fibroblast Growth Factor, Is Important in the Switch to the Angiogenic Phenotype During Early Tumorigenesis","volume":"61","author":"Fang J.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_8_11_1","first-page":"559","article-title":"A Unique Microvascular Phenotype Shared by Juvenile Hemangiomas and Human Placenta","volume":"137","author":"North P. 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