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Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity. This means the distribution of different subclones into individual skin lesions and the accumulation of genomic and epigenomic changes in known pathways, starting from immature T\u2010cell precursors. MF is now recognized as the proliferation of multiple mutational subclones that originate from immature T\u2010cell precursors with malignant potential. This may explain why there are so many case reports of MF accompanied by T\u2010cell lymphoproliferative disorders or cutaneous T\u2010cell lymphomas. 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