{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:08:41Z","timestamp":1776100121938,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Two\u2010year effectiveness of tyrosine kinase 2 inhibitor deucravacitinib is unknown for psoriasis in real\u2010world, especially in patients with different histories of systemic therapy. To evaluate the 104\u2010week effectiveness of deucravacitinib in patients with psoriasis, stratified by prior use of apremilast or biologics. We studied 131 patients with moderate\u2010to\u2010severe psoriasis who received deucravacitinib 6\u2009mg\/day. Psoriasis area and severity index (PASI) and dermatology life quality index (DLQI) were analyzed in subgroups stratified by prior apremilast or biologic therapy. Deucravacitinib decreased PASI and DLQI through 104\u2009weeks regardless of prior apremilast or biologic therapy. Week 104 achieving PASI 100 and absolute PASI \u2264\u20091 were higher in apremilast\u2010na\u00efve patients (15.4% and 53.8%) than in apremilast\u2010experienced patients (0% and 25%, respectively). Week 104 achieving PASI 75, PASI 90, PASI 100, and absolute PASI \u2264\u20091 were higher in biologic\u2010na\u00efve patients (84.6%, 57.7%, 15.4%, and 53.8%) than in biologic\u2010experienced patients (25%, 25%, 0%, and 25%, respectively). Deucravacitinib reduced PASI and DLQI through 104\u2009weeks in patients with psoriasis regardless of prior apremilast or biologic therapy, with lower sustainability of PASI 100 or absolute PASI \u2264\u20091 achievements in patients with prior apremilast or biologic treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.70175","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:55:58Z","timestamp":1770630958000},"page":"683-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010Year Real\u2010World Effectiveness of Deucravacitinib in Psoriasis: The Analysis Stratified by Prior Apremilast or Biologic Therapy"],"prefix":"10.1111","volume":"53","author":[{"given":"Ryo","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai 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