{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:08:31Z","timestamp":1776100111054,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dermatomyositis (DM) can present initially with respiratory symptoms and may be misdiagnosed as infection or other pulmonary disorders, leading to delayed recognition and worse outcomes. We aimed to characterize this respiratory\u2010onset phenotype and to evaluate whether elbow Gottron's sign is associated with respiratory\u2010onset and clinically meaningful adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective cohort study of 190 DM patients. Respiratory\u2010onset was defined as respiratory symptoms documented as the first presenting complaint (cough, sputum production, wheezing, chest tightness, dyspnea, and\/or auscultatory Velcro crackles); imaging findings were not used to define onset phenotype. Outcomes included respiratory failure (primary), progressive ILD, and death. Multivariable logistic regression and ROC analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The initial symptoms of DM patients with respiratory system manifestations are mostly cough, sputum, wheezing, chest tightness, fever, and Velcro rales. Laboratory tests show that erythrocyte sedimentation rate, lactate dehydrogenase, anti\u2010MDA5 antibody, anti\u2010RO\u201052 antibody, carcinoembryonic antigen, and ferritin are all higher in this group compared to those with initial symptoms from other systems. ROC curve analysis demonstrated that elbow Gottron's sign alone provided modest but significant predictive value for respiratory failure (AUC\u2009=\u20090.668). Notably, a combined model incorporating both respiratory symptoms and elbow Gottron's sign showed significantly improved discriminative performance (AUC\u2009=\u20090.765). These findings support the role of elbow Gottron's sign as a clinically relevant marker for identifying dermatomyositis with respiratory onset and for stratifying the risk of respiratory failure in this patient subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Respiratory\u2010onset identifies a clinically meaningful high\u2010risk DM phenotype with substantially increased respiratory failure. Elbow Gottron's sign is a readily observable cutaneous clue that may facilitate earlier recognition and risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1346-8138.70179","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:55:52Z","timestamp":1770702952000},"page":"662-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elbow Gottron's Sign as a Predictor of Dermatomyositis With Respiratory System as the Initial Manifestation: A Retrospective Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Allergy Jiangnan University Medical Center  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelei","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Jiangnan University  Wuxi China"},{"name":"Wuxi Clinical College, Nantong University  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Jiangnan University  Wuxi China"},{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Kunshan Second People's Hospital  Kunshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinye","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningjing","family":"You","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Bi","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-3634","authenticated-orcid":false,"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Jiangnan University  Wuxi China"},{"name":"Wuxi Clinical College, Nantong University  Nantong China"},{"name":"School of Medicine Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784\u20108671.23.07458\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010017\u20108652\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170165"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.11.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24786"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010019\u201004910\u2010w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2478\/rir\u20102022\u20100001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.11.005"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"99","article-title":"Anti\u2010MDA5 Dermatomyositis. Literature Review","volume":"61","author":"Castro\u2010Molina S. A.","year":"2023","journal-title":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27791"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2024.01.002"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3604\u201019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.09.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31827ebba1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001000"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20106958\u20108\u201027"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.833114"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.05.011"},{"issue":"43","key":"e_1_2_11_20_1","first-page":"3402","article-title":"Interstitial Lung Disease as an Initial Manifestation of Dermatomyosit Is","volume":"94","author":"Shen M.","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106134"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.04.020"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005382\u2010199203000\u201000006"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22026"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/loae018"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3531"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346\u20108138.1998.tb02342.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57070692"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160024"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42526"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1921_19"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021899"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010018\u20103146\u20107"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312118781895"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:09:30Z","timestamp":1776096570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/1346-8138.70179"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70179","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}