{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:08:23Z","timestamp":1776100103208,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has been reported to be effective and tolerable for moderate\u2010to\u2010severe palmoplantar pustulosis (PPP) in clinical trials, but real\u2010world data are limited. To evaluate the 28\u2010week real\u2010world effectiveness of apremilast in patients with PPP. We conducted a single\u2010center, retrospective study of 15 adult patients (\u2265\u200918\u2009years) with moderate\u2010to\u2010severe PPP (baseline physician's global assessment score \u2265\u20093) who required systemic treatment because topical therapy alone was insufficient or unsuitable. Patients received apremilast 30\u2009mg twice daily. Palmoplantar Pustulosis Area and Severity Index (PPPASI) and Dermatology Life Quality Index (DLQI) were assessed at weeks 0, 4, 16, and 28 of treatment. Mean PPPASI and DLQI scores decreased continuously through Week 28. At Week 28, mean percent reductions of PPPASI and DLQI from baseline were 76.9% and 63.4%, respectively. Week 28 rates achieving PPPASI 50, PPPASI 75, PPPASI 90, and DLQI 0\/1 were 90.0%, 60.0%, 30.0%, and 42.9%, respectively. Treatment\u2010emergent adverse events were diarrhea in six patients, leading to discontinuation of apremilast in one patient. No serious adverse events occurred. These findings suggest that apremilast treatment is effective and tolerable for PPP patients requiring systemic treatment in routine practice. Further studies with larger cohorts and longer observation are required to confirm the sustainability of its clinical benefits.<\/jats:p>","DOI":"10.1111\/1346-8138.70184","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:35:33Z","timestamp":1770813333000},"page":"704-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Apremilast in Patients With Palmoplantar Pustulosis: A 28\u2010Week Real\u2010World Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Yohei","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-9596","authenticated-orcid":false,"given":"Teppei","family":"Hagino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eita","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujimoto Dermatology Clinic  Funabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-2312","authenticated-orcid":false,"given":"Naoko","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.03.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010020\u201000503\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2011.01325.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.70166"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15382"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2009.03296.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:09:19Z","timestamp":1776096559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/1346-8138.70184"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70184","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"2026-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}