{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:53:19Z","timestamp":1791985999597,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus, barrier dysfunction, and complex immune dysregulation. Phototherapy with narrow\u2010band ultraviolet B (NB\u2010UVB) or 308\u2009nm excimer devices is clinically effective for AD, but the underlying mechanisms remain incompletely understood. In this study, we investigated the therapeutic effects of a 308\u2010nm excimer lamp using a murine model of AD induced by topical application of the vitamin D3 analog MC903. C57BL\/6 mice were treated with MC903 for 13 consecutive days, with or without irradiation by a 308\u2010nm excimer lamp at 100\u2009mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    every other day. Clinical severity was assessed daily, and histological, immunohistochemical, and molecular analyses were performed on lesional skin. Excimer irradiation significantly alleviated MC903\u2010induced dermatitis from days 4 to 12, with reduced clinical severity scores, epidermal thickness, and acanthosis compared with non\u2010irradiated controls. Immunohistochemical analysis revealed a significant decrease in intraepidermal PGP9.5\u2010positive nerve fibers in irradiated mice, suggesting that excimer therapy attenuates pruritus through neuroimmune modulation. Furthermore, excimer irradiation increased dermal infiltration of Foxp3\u2010positive regulatory T cells and decreased plasma IgE levels, although no significant upregulation of IL\u201010 mRNA was detected. Importantly, quantitative PCR demonstrated that excimer irradiation reduced thymic stromal lymphopoietin (TSLP) expression in lesional skin, while levels of other Th2\u2010related cytokines such as IL\u20104 and IL\u201013 remained unchanged. These findings indicate that 308\u2010nm excimer lamp therapy ameliorates AD\u2010like dermatitis through dual mechanisms: suppression of intraepidermal nerve fibers and downregulation of epithelial\u2010derived TSLP, together with enhanced regulatory T\u2010cell infiltration. This study provides new mechanistic insights into the immunological and neurocutaneous effects of excimer phototherapy, supporting its clinical use in AD and potentially other inflammatory skin diseases.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70209","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:07:42Z","timestamp":1772993262000},"page":"810-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A 308\u2010nm Excimer Lamp Ameliorates\n                    <scp>MC903<\/scp>\n                    \u2010Induced Atopic Dermatitis With Reductions of Intraepidermal Nerve Fiber Density and Expression of Thymic Stromal Lymphopoietin"],"prefix":"10.1111","volume":"53","author":[{"given":"Thalita","family":"Bastos","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-4982","authenticated-orcid":false,"given":"Masahiro","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Tomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Hiura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Fukuyasu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3743-135X","authenticated-orcid":false,"given":"Yayoi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005374"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130351"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.446"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.318"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2116"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01495.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.3.461"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00004314"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051262"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01316.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1687825"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.042"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.06.004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1548"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.256"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201108111"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1788"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000300"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.59717\/j.xinn-life.2026.100187"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.028"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.01.004"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:36:29Z","timestamp":1791984989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/1346-8138.70209"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70209","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,7]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}