{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:07:31Z","timestamp":1780466851955,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lichen amyloidosis (LA) is a chronic, intensely itchy skin disease that is often difficult to control with conventional therapies. Interleukin\u201031 (IL\u201031) is an itch\u2010driving cytokine, and nemolizumab, an antibody to the IL\u201031 receptor, has become available for some pruritic dermatoses. We report a man in his 60s with a 6\u2010year history of treatment\u2010refractory LA on the trunk and extremities. He received nemolizumab 60\u2009mg subcutaneously every 4\u2009weeks because of persistent severe itch despite topical therapy. Itch intensity improved from 5\/10 at baseline to 2\/10 at Week 4 and to 1\/10 at Week 8, remaining low thereafter. The papular lesions showed marked flattening and regression after five doses, leaving only faint residual pigmentation. Serum IL\u201031 concentrations were measured immediately before each injection using a commercial assay. Values decreased after Week 4, reached the lowest level by Week 12 during near\u2010complete remission, and showed a mild increase by Week 16 without clinical relapse. This case suggests that blocking IL\u201031 signaling can rapidly and durably improve severe LA and that repeated serum IL\u201031 measurements may help support treatment response over time.<\/jats:p>","DOI":"10.1111\/1346-8138.70263","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:50:09Z","timestamp":1775886609000},"page":"948-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nemolizumab for Lichen Amyloidosis With Serial Serum Interleukin\u201031 Levels: A Case Report"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-7256","authenticated-orcid":false,"given":"Tsuyoshi","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Dermatology Iwate Medical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakako","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwate Medical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-7550","authenticated-orcid":false,"given":"Daisuke","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwate Medical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-4661","authenticated-orcid":false,"given":"Hiroo","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwate Medical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12581609"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12531130"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1970.04000070010002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/16.11.673"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70066-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09311.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1084"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2025.06.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.227"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1829"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14391"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0278-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12144"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:31:15Z","timestamp":1780464675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/1346-8138.70263"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70263","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}