{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:07:36Z","timestamp":1780466856244,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a case of Japanese spotted fever (JSF) showing marked serological cross\u2010reactivity with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Rickettsia typhi<\/jats:italic>\n                    <\/jats:styled-content>\n                    , which made serological differentiation difficult. An 80\u2010year\u2010old man presented with fever and disseminated erythematous macules. Laboratory finding suggested a rickettsial infection. Minocycline treatment led to clinical improvement. Real\u2010time polymerase chain reaction screening was positive for spotted fever group rickettsiae. Serological testing using paired sera demonstrated comparable increases in antibody titers against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>R. japonica<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>R. typhi<\/jats:italic>\n                    <\/jats:styled-content>\n                    in the convalescent phase, precluding differentiation based on serology alone. Sequence\u2010based molecular analysis using DNA extracted from the patient's serum revealed 100% identity with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>R. japonica<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain YH, leading to a definitive diagnosis of JSF. This case highlights the diagnostic challenges posed by serological cross\u2010reactivity and underscores the clinical value of molecular diagnostic approaches when serological findings are inconclusive.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70265","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:20:38Z","timestamp":1775625638000},"page":"956-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Japanese Spotted Fever With Marked Serological Cross\u2010Reactivity to\n                    <scp>\n                      <i>Rickettsia typhi<\/i>\n                    <\/scp>\n                    Confirmed by Sequence\u2010Based Molecular Analysis: A Case Report"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1869-1346","authenticated-orcid":false,"given":"Natsumi","family":"Fushida","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-7770","authenticated-orcid":false,"given":"Yasuhito","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Hodatsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japan Community Health Care Organization, Kanazawa Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Koshida","sequence":"additional","affiliation":[{"name":"Kanazawa City Public Health Center  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Bacteriology I National Institute of Infectious Diseases, Japan Institute of Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Bacteriology I National Institute of Infectious Diseases, Japan Institute of Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101319"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1995.tb03298.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.03.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0529-x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:30:42Z","timestamp":1780464642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/1346-8138.70265"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70265","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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