{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:03:41Z","timestamp":1783454621327,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pustular mycosis fungoides (pMF) is a rare variant of MF characterized by the clinical and histopathological formation of pustules. We report a 71\u2010year\u2010old Japanese woman with established MF who developed a generalized pustular eruption temporally triggered by systemic interferon (IFN)\u2010\u03b3 administration. Clinically, the patient presented with generalized erythema with coalescing pustules mimicking generalized pustular psoriasis or acute generalized exanthematous pustulosis. Histological examination revealed the simultaneous presence of spongiform pustules of Kogoj and large transformed CD30\n                    <jats:sup>+<\/jats:sup>\n                    atypical lymphoid cells. The pustules resolved rapidly upon the discontinuation of IFN\u2010\u03b3 and the administration of systemic antibiotics. Cytokine analysis at the onset of pustulosis revealed marked elevations in serum IL\u20108, IL\u201018, IL\u201023, and IL\u20106 compared with healthy controls; these levels normalized during remission. This case suggests that systemic IFN\u2010\u03b3 can act as a trigger for pMF. Furthermore, the distinct cytokine profile highlights that the IL\u201023\/IL\u201017\/IL\u20108 axis may be a crucial mediator in the pathogenesis of pMF.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70278","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:12:41Z","timestamp":1776687161000},"page":"1032-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pustular Mycosis Fungoides Triggered by Systemic Interferon\u2010\u03b3"],"prefix":"10.1111","volume":"53","author":[{"given":"Mai","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"},{"name":"Department of Dermatology Iwata City Hospital  Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-869X","authenticated-orcid":false,"given":"Takatoshi","family":"Shimauchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwata City Hospital  Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-1549","authenticated-orcid":false,"given":"Kazuo","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-7571","authenticated-orcid":false,"given":"Reiko","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-4592","authenticated-orcid":false,"given":"Kazumitsu","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-4869","authenticated-orcid":false,"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1951.01570090002001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600200077013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae312"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.012"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"74","article-title":"Generalized Pustular Psoriasis: Immunological Mechanisms, Genetics, and Emerging Therapeutics","volume":"46","author":"Lee C. 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