{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:46:17Z","timestamp":1785836777109,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mohs paste (MP), a zinc chloride\u2013based tissue fixative developed by Frederic E. Mohs, was historically central to skin cancer treatment but declined worldwide following the adoption of the fresh\u2010tissue technique and Mohs micrographic surgery (MMS). Japan remains a notable exception; MMS is not as widely adopted there, while MP persists as a symptom\u2010directed practice across multiple disciplines. We systematically characterized the indications, applications, and limitations of MP to contextualize its contemporary clinical relevance. Following PRISMA\u2010ScR guidelines, PubMed and Scopus were searched through March 2025 for peer\u2010reviewed reports describing the clinical use of Mohs paste, ointment, or chemosurgery as therapeutic interventions for surface or ulcerative lesions. Reports using MP solely as an adjunct within MMS or those without original cases were excluded, and data were synthesized thematically. Fifty\u2010two studies (1964\u20132024) described 88 patients (36 case reports; 16 case series), predominantly from Japan (48 reports). Patients were mostly female (80.7%) with a median age of 68\u2009years, and most presented with locally advanced or stage III\u2013IV disease. Indications included breast, gynecologic, head and neck, and skin cancers, alongside metastatic cutaneous tumors, sarcomas, and oral cancers, with isolated reports of chronic ulcers and schwannoma. At least one local outcome was reported in 87 patients (98.9%), based on descriptive and non\u2010standardized reporting. Frequently reported local outcomes included bleeding control (78.4%), reduction of exudate (62.5%), reduction of malodor (47.7%), and reduction of tumor volume (44.3%). The most commonly reported adverse event was pain, which required analgesics in some cases. MP was occasionally used concurrently with systemic drug therapy or radiotherapy to stabilize local symptoms. Overall, MP has evolved into a pragmatic, symptom\u2010directed intervention bridging oncology and palliative care. These findings highlight the need for standardized protocols, registry\u2010based evaluation, and clearer positioning of MP within contemporary clinical practice.<\/jats:p>","DOI":"10.1111\/1346-8138.70321","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:09:21Z","timestamp":1780027761000},"page":"1083-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistence and Contemporary Clinical Applications of\n                    <scp>M<\/scp>\n                    ohs Paste: A Scoping Review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1193-8631","authenticated-orcid":false,"given":"Airin","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Academic Assembly, University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-6899","authenticated-orcid":false,"given":"Yu","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Academic Assembly, University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-8997","authenticated-orcid":false,"given":"Shohei","family":"Kitayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Academic Assembly, University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Academic Assembly, University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.12.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.12767"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.14030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346\u20108138.2010.00898.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525751"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.17605\/OSF.IO\/JREBG"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_2090_21"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.33235\/wpr.30.3.150\u2010157"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365809"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105817"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.47.429"},{"key":"e_1_2_11_14_1","first-page":"8","article-title":"Chemosurgical Ointment","volume":"24","author":"Ohkubo T.","year":"2000","journal-title":"Japanese Red Cross Takayama Hospital Medical Journal"},{"issue":"8","key":"e_1_2_11_15_1","first-page":"1829","article-title":"Japanese Clinical Practice Guidelines for Skin Cancer 2025: Basal Cell Carcinoma","volume":"135","author":"Japanese Dermatological Association","year":"2025","journal-title":"Nippon Hifuka Gakkai Zasshi"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.12207"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2024_91\u2010308"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2012.0219"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.13107\/jocr.2023.v13.i10.3924"}],"container-title":["The Journal of 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