{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:02:09Z","timestamp":1783454529428,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Standard\u2010dose rituximab (SDRTX) is the established treatment for pemphigus, but optimization of cost\u2010effectiveness and safety remains desirable. We retrospectively evaluated the efficacy of a single ultra\u2010low dose RTX infusion (ULRTX; 100 or 200\u2009mg) for remission induction in 12 patients with mild\u2010to\u2010severe pemphigus (median baseline Pemphigus Disease Area Index [PDAI] 29.5). 9 patients (75%) achieved complete remission on minimal therapy (CRMT), and among them 5 (41.7%) subsequently achieved complete remission off therapy (CROT), with a median time to CRMT and CROT of 24\u2009weeks and 61\u2009weeks, respectively. Significant corticosteroid sparing was achieved; 9 of 10 evaluable patients tapered prednisolone to \u2264\u20095\u2009mg\/day within 6\u2009months. Despite the reduced dose of RTX, an overall decline in serum anti\u2010desmoglein 1 and 3 IgG titers and effective peripheral B\u2010cell depletion (\u2264\u20091%) occurred in evaluable patients. However, early B\u2010cell repopulation was observed in one patient who experienced an early relapse. Compared with the standard\u2010dose group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098), the ULRTX group demonstrated a favorable safety profile with significantly fewer drug\u2010related adverse events (0% vs. 37.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049), while maintaining effective clinical remission. Single\u2010dose ULRTX appears to be a cost\u2010efficient and biologically effective induction strategy, supporting a personalized, immunologically guided, on\u2010demand treatment approach.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70322","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:24:26Z","timestamp":1779513866000},"page":"1057-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Experience With Single Ultra\u2010Low Dose Rituximab for Remission Induction in Pemphigus"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-7392","authenticated-orcid":false,"given":"Yu\u2010Chen","family":"Jeng","sequence":"first","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-9486","authenticated-orcid":false,"given":"Wei\u2010Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-4533","authenticated-orcid":false,"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_1266_24"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16752"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2011.10663.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15213"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017934\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1727440"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.16145"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20819"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.1506"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.05.1374"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"}],"container-title":["The 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