{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:03:23Z","timestamp":1783454603877,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Atopic dermatitis is a chronic inflammatory skin disease that commonly begins in childhood but exhibits heterogeneous long\u2010term clinical courses. We conducted a cross\u2010sectional questionnaire survey among dermatologists to evaluate age\u2010specific prevalence, remission proportion, severity, and disease course of atopic dermatitis in Japan. Data from 7777 individuals, including respondents and their family members, were analyzed. The prevalence of atopic dermatitis peaked at 5\u20139\u2009years of age and gradually declined with age, although a substantial proportion of affected individuals remained in adulthood. Overall, prevalence was higher in males than in females, with a significant difference observed in the youngest age group. The proportion of individuals with a remitted disease course increased with age and plateaued after approximately 40\u2009years. Remission proportions were higher in females than in males overall, although age\u2010specific differences were not consistently significant. Most cases were almost clear or mild; however, moderate\u2010to\u2010severe disease was observed in a subset of individuals across age groups, without marked sex differences. Regarding disease course, remission after childhood onset was the most common pattern, followed by relapse, persistence, and adult\u2010onset disease. Remission\u2010type courses were more frequent in females, whereas persistent and relapsing patterns were more common in males. These findings suggest that atopic dermatitis persists into adulthood in a substantial proportion of individuals and follows diverse clinical trajectories across the lifespan.<\/jats:p>","DOI":"10.1111\/1346-8138.70329","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:16:59Z","timestamp":1779769019000},"page":"990-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence, Severity, and Clinical Course of Atopic Dermatitis in Japan: A Web\u2010Based Questionnaire Survey"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-8273","authenticated-orcid":false,"given":"Takeshi","family":"Nakahara","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-8505","authenticated-orcid":false,"given":"Sakae","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Masuda Red Cross Hospital  Masuda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-2482","authenticated-orcid":false,"given":"Norito","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department for Medical Innovation and Translational Medical Science Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Toshoguekimae Dermatology Clinic  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kanoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu Municipal Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-755X","authenticated-orcid":false,"given":"Yutaka","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Oita University  Yufu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Watanabe Dermatology and Plastic Surgery Clinic  Ueda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Sumikawa","sequence":"additional","affiliation":[{"name":"Dermatology &amp; Allergy CLINIC Hokutoukai Medical Corporation  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-9188","authenticated-orcid":false,"given":"Daisuke","family":"Onozuka","sequence":"additional","affiliation":[{"name":"Department of Post\u2010Infectious Diseases Therapeutics, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-7064","authenticated-orcid":false,"given":"Akio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences, Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-0134","authenticated-orcid":false,"given":"Yoko","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka Habikino Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-1377","authenticated-orcid":false,"given":"Hiroyuki","family":"Murota","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15664"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"1526","article-title":"Adult\u2010Onset Atopic Dermatitis","volume":"143","author":"Silverberg J. 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