{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:45:49Z","timestamp":1785836749817,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015990","name":"Sanofi K.K.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinical phenotypes of atopic dermatitis (AD) can vary, with some individuals displaying difficult\u2010to\u2010treat prurigo nodularis\u2010like lesions. We aimed to assess the real\u2010world disease burden and treatment course of Japanese adults with AD\u2010associated prurigo nodules (AD\u2010Pn) receiving conventional AD treatments. Of the 300 participants with moderate\u2010to\u2010severe AD registered in the observational ADDRESS\u2010J study between July 29, 2016 and July 4, 2017 (before the first biologic for AD was introduced), 285 had baseline and post\u2010baseline prurigo assessments and were included in this exploratory analysis (108 with AD\u2010Pn and 177 without Pn). Participants with AD\u2010Pn versus those without Pn included more males (73.1% vs. 53.1%), and had more mean\u2009\u00b1\u2009standard deviation (SD) visits for AD treatment in the previous year (11.5\u2009\u00b1\u200916.1 vs. 8.7\u2009\u00b1\u20096.6 visits), a higher proportion with an Investigator's Global Assessment (IGA) 4 score (39.9% vs. 18.6%), a higher mean\u2009\u00b1\u2009SD Eczema Area and Severity Index (EASI) score (28.4\u2009\u00b1\u200915.1 vs. 23.5\u2009\u00b1\u200915.5), and a higher mean\u2009\u00b1\u2009SD Patient\u2010Oriented Eczema Measure (POEM) score (18.8\u2009\u00b1\u20096.2 vs. 15.6\u2009\u00b1\u20096.8). At baseline, 14.8% and 7.4% of participants with AD\u2010Pn had been treated with oral immunosuppressants and oral corticosteroids, respectively, compared with 8.5% and 2.3%, respectively, of those without Pn. Individuals with AD\u2010Pn previously received more intensive topical treatments. At 2 years, participants with AD\u2010Pn had more severe AD than those without Pn, as assessed by IGA 4 scores (9.1% vs. 0.9%), and higher mean\u2009\u00b1\u2009SD EASI total scores (12.5\u2009\u00b1\u200910.7 vs. 7.0\u2009\u00b1\u20098.1). In summary, individuals with AD\u2010Pn were mostly males, whose AD was more severe and had improved less than those without Pn while receiving mostly conventional AD treatments over 2 years. AD\u2010Pn might be an indicator for targeted treatment to improve long\u2010term AD outcomes.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                    ADDRESS\u2010J (UMIN Clinical Trial Registration: UMIN000022623)\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70345","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:05:09Z","timestamp":1783058709000},"page":"1099-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Prurigo Nodules in Adults With Moderate\u2010To\u2010Severe Atopic Dermatitis in Japan: A 2\u2010Year Observational Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-0134","authenticated-orcid":false,"given":"Yoko","family":"Kataoka","sequence":"first","affiliation":[{"name":"Department of Dermatology Osaka Habikino Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0495-9064","authenticated-orcid":false,"given":"Takafumi","family":"Etoh","sequence":"additional","affiliation":[{"name":"Atago Dermatology Clinic  Tokyo Japan"},{"name":"Department of Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-2482","authenticated-orcid":false,"given":"Norito","family":"Katoh","sequence":"additional","affiliation":[{"name":"North Campus Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-0597","authenticated-orcid":false,"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3405-6136","authenticated-orcid":false,"given":"Yuki","family":"Tajima","sequence":"additional","affiliation":[{"name":"Sanofi K.K  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwinten","family":"Bosman","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Ardeleanu","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-8787","authenticated-orcid":false,"given":"Kazuhiko","family":"Arima","sequence":"additional","affiliation":[{"name":"Sanofi K.K  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223211002979"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14787"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17544"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.035"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246715"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12943"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00697-w"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000895"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.10.058"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100102.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20957"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10498.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04481.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.1196"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02320-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1853024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301333"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16485"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.08.009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1513"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15090"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3701"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.05.034"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15145"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.183"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:01:13Z","timestamp":1785834073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/1346-8138.70345"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70345","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}