{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:45:49Z","timestamp":1785836749938,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23AA2003"],"award-info":[{"award-number":["23AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Amenamevir is a novel anti\u2010herpes zoster drug that is increasingly used in Japan because of its once\u2010daily administration and lack of renal dose adjustment requirements. However, evidence of its clinical effectiveness is limited. This study aimed to estimate the clinical effectiveness of amenamevir vs. valacyclovir in preventing zoster\u2010related hospitalizations and complications. Using a nationally representative claims database from 2017 to 2024, we conducted a retrospective cohort study with a new\u2010user, active\u2010comparator design. We included adults (aged \u2265\u200918\u2009years) with uncomplicated herpes zoster who initiated amenamevir or valacyclovir treatment. Propensity score overlap weighting was used to adjust for differences between patients prescribed amenamevir and valacyclovir. The primary outcome was 30\u2010day zoster\u2010related hospitalization. The secondary outcomes included diagnoses of zoster\u2010related complications (zoster encephalitis, zoster meningitis, disseminated zoster, and zoster ocular disease) and acute kidney injury. In total, 67\u2009912 individuals (38.2% male; mean age, 70.1\u2009years) were included. After overlap weighting, baseline covariates were well\u2010balanced between the groups. The risk of 30\u2010day zoster\u2010related hospitalization was similar between amenamevir and valacyclovir users (0.73% vs. 0.73%; risk ratio [RR], 1.00; 95% confidence interval [CI], 0.84\u20131.20). For secondary outcomes, zoster encephalitis (0.02% vs. 0.01%; RR, 2.09; 95% CI, 0.62\u20137.10), zoster meningitis (0.04% vs. 0.02%; RR, 2.32; 95% CI, 0.89\u20136.09), and disseminated zoster (0.13% vs. 0.10%; RR, 1.25; 95% CI, 0.79\u20131.97) did not differ significantly between the groups. However, amenamevir was associated with a higher risk of zoster ocular disease (0.84% vs. 0.67%; RR, 1.25; 95% CI, 1.05\u20131.49) and a lower risk of acute kidney injury (0.02% vs. 0.09%; RR, 0.23; 95% CI, 0.10\u20130.53). Based on our findings, amenamevir may be a useful option for herpes zoster, particularly in clinical settings where timely assessment of renal function is not available. However, caution is warranted regarding possible increases in ocular complications.<\/jats:p>","DOI":"10.1111\/1346-8138.70349","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:25:20Z","timestamp":1781069120000},"page":"1115-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Amenamevir Vs. Valacyclovir in Preventing Herpes Zoster\u2010Related Hospitalization and Complications: A Target Trial Emulation Using a Large Japanese Claims Database"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-2859","authenticated-orcid":false,"given":"Yasuhiro","family":"Kano","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"},{"name":"Department of Emergency and General Medicine Tokyo Metropolitan Tama Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-0596","authenticated-orcid":false,"given":"Yuya","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Graduate School of Medicine University of Tokyo  Tokyo 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