{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:44:38Z","timestamp":1791989078497,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u20101133801A"],"award-info":[{"award-number":["TCVGH\u20101133801A"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u20101140802D"],"award-info":[{"award-number":["TCVGH\u20101140802D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Real\u2010world evidence on the treat\u2010to\u2010target strategy in atopic dermatitis (AD) remains limited. To evaluate targeted combined endpoints in AD, we conducted a cross\u2010sectional study that included 100\u2009adults with AD receiving treatment \u2265\u20096\u2009months. Targeted endpoints included Patient Global Assessment (PGA) \u2264\u20092, Eczema Area and Severity Index (EASI) \u2264\u20097, visual analog scale (VAS) of pruritus \u2264\u20094, Patient Oriented Eczema Measure (POEM) \u2264\u20097, and Dermatology Life Quality Index (DLQI) \u2264\u20095. Logistic regression and receiver operating characteristic (ROC) curve analysis were performed to identify factors associated with achieving treatment targets. Latent class analysis (LCA) and principal component analysis (PCA) were performed to identify patient subgroups and data components. Only 30% met all five targeted endpoints. An increased age was associated with a higher probability of achieving all treatment targets (aOR: 1.04; 95% CI: 1.00\u20131.09). DLQI could favorably predict the achievement of all 5 treatment targets (AUROC: 0.93; 95% CI: 0.88, 0.97). Despite no significant differences across treatment groups, the proportion of patients achieving all targets was the highest in the dupilumab group, followed by the Janus kinase inhibitor (JAKi) group. LCA identified one subgroup of patients achieving favorable skin control but poor life quality. PCA showed that life quality\u2010related factors other than the severity of skin lesions explained the majority of variance. In conclusion, achievement of targeted combined endpoints in AD remains suboptimal, partly due to life quality\u2010related factors.<\/jats:p>","DOI":"10.1111\/1346-8138.70369","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:37:27Z","timestamp":1783143447000},"page":"1315-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Achieving Targeted Combined Endpoints in Patients With Atopic Dermatitis: A Real\u2010World Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-5355","authenticated-orcid":false,"given":"Yun\u2010Wen","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of General Medicine, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Animal Science and Biotechnology Tunghai University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsing","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of Allergy, Center of Rheumatology &amp; Immunology China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-2665","authenticated-orcid":false,"given":"Tsai\u2010Hung","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of General Medicine, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Da","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-3065","authenticated-orcid":false,"given":"Yi\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-6957","authenticated-orcid":false,"given":"Tsu\u2010Yi","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of Clinical Training, Department of Medical Education Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"College of Business and Management Ling Tung University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-1329","authenticated-orcid":false,"given":"Kuo\u2010Tung","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Ph.D. Program in Translational Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000687"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1513"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.055"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12959"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3751"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.01.053"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20229"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01469-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01485-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v104.18452"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.09.043"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S223092"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117945"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.03.024"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.42794"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14763"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012153"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00754-4"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.017"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.08.102"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.043"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.052"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03112.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:49:21Z","timestamp":1791985761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/1346-8138.70369"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70369","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}