{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:46:17Z","timestamp":1785836777046,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nail apparatus melanoma (NAM) is a biologically and clinically distinct subtype of melanoma; however, the efficacy of adjuvant interferon (IFN) therapy in this population remains unclear. We conducted a multicenter retrospective study to compare adjuvant IFN\u2010\u03b2 (adj\u2010IFN) with observation (OBS) in patients with resected stage IIB, IIC, or III NAM. We analyzed 282 Japanese patients treated at 42 institutions between 2014 and 2024. Recurrence\u2013free survival (RFS) and distant metastasis\u2013free survival (DMFS) were co\u2010primary outcomes, and overall survival (OS) was a secondary outcome. Survival outcomes were assessed using Kaplan\u2013Meier analyses and Cox multivariable proportional hazards models. To minimize the differences of baseline characteristics between the two groups, propensity score matching (PSM) was applied. In multivariable Cox analyses, adj\u2010IFN showed improved RFS (HR 0.67, 95% CI 0.45\u20130.998,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049), while no statistically significant benefits were observed for DMFS (HR 0.66, 95% CI 0.42\u20131.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.06) or OS (HR 0.85, 95% CI 0.54\u20131.35,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.50) compared with OBS. After PSM (71 patients per group), survival outcomes were comparable between the two groups, with no statistical significance in RFS (HR 0.71, 95% CI 0.45\u20131.12,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.14), DMFS (HR 0.73, 95% CI 0.44\u20131.20,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.22), or OS (HR 1.01, 95% CI 0.58\u20131.78,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.96). In conclusion, no significant survival advantage of adj\u2010IFN over observation was demonstrated in the matched cohort. Although a borderline association with improved RFS was observed in the overall cohort, this finding did not translate into consistent benefit across endpoints. Further prospective evidence, including the final results of the randomized phase III trial (JCOG1309, J\u2010FERON), is required to clarify the clinical role of adj\u2010IFN in NAM.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70375","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:14:42Z","timestamp":1783401282000},"page":"1124-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Adjuvant Interferon\u2010\u03b2 Versus Observation for Resected Nail Apparatus Melanoma: A Multicenter Retrospective Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-7735","authenticated-orcid":false,"given":"Takaya","family":"Komori","sequence":"first","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center  Saitama Japan"},{"name":"Department of Dermatology Kindai University Faculty of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-8182","authenticated-orcid":false,"given":"Eiji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-7375","authenticated-orcid":false,"given":"Yukiko","family":"Kiniwa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8617-6444","authenticated-orcid":false,"given":"Sotaro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6082-4696","authenticated-orcid":false,"given":"Shusuke","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology\/Dermatology Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Oncology NHO Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-944X","authenticated-orcid":false,"given":"Tatsuya","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Niigata Cancer Center Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keijun","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ohe","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine  Kanagawa 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School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-621X","authenticated-orcid":false,"given":"Toshihiko","family":"Hoashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-411X","authenticated-orcid":false,"given":"Takayuki","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine  Kobe 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