{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:44:38Z","timestamp":1791989078501,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Extramammary Paget's disease (EMPD) is a rare cutaneous carcinoma that typically arises in apocrine gland\u2013rich areas. Advanced or metastatic disease is associated with poor prognosis and limited therapeutic options. Due to its rarity, no standard chemotherapy regimen has been established. Agents such as docetaxel, cisplatin, and 5\u2010fluorouracil have been used, but evidence supporting their efficacy remains limited. Etoposide has occasionally been reported to provide temporary benefit in advanced EMPD, although its effectiveness remains poorly characterized. We report a case series of three patients with metastatic EMPD treated with oral etoposide as third\u2010 or fourth\u2010line therapy. They had experienced disease progression despite prior therapies, including docetaxel, S\u20101, and low\u2010dose FP (5\u2010fluorouracil and cisplatin) therapy. Oral etoposide was administered at 50\u2009mg\/day for 3\u20134\u2009weeks followed by a 1\u20132\u2009week rest period. Additional radiation therapy was provided for metastatic lesions in two patients. Two patients achieved a partial response on imaging, while one showed stable disease. Serum carcinoembryonic antigen levels decreased markedly in two evaluable patients, indicating a biological response. The average progression\u2010free survival was 7.7\u2009months. Adverse events included alopecia and neutropenia in one patient, both manageable. Although all patients eventually died from disease progression, etoposide provided disease control and symptomatic relief. These findings suggest that oral etoposide may represent a feasible and relatively well\u2010tolerated late\u2010line treatment option for metastatic EMPD.<\/jats:p>","DOI":"10.1111\/1346-8138.70382","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:32:42Z","timestamp":1783657962000},"page":"1371-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Etoposide as Late\u2010Line Therapy for Metastatic Extramammary Paget's Disease: A Case Series"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-6498","authenticated-orcid":false,"given":"Takanobu","family":"Kan","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima 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Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-7064","authenticated-orcid":false,"given":"Akio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima 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