{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:55:06Z","timestamp":1791446106708,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic\u2010na\u00efve psoriasis patients. Whether MACE risk among biologic\u2010treated patients varied by race was further examined. After 1:1 propensity score matching, 36\u2009330 biologic\u2010treated patients were compared with 36\u2009330 non\u2010biologic\u2010treated patients. Incident MACE was assessed over 10\u2009years. Class\u2010specific analyses evaluated mutually exclusive biologic exposure groups, including TNF inhibitors (TNFi), IL\u201017 inhibitors (IL\u201017i), IL\u201012\/23 inhibitors (IL\u201012\/23i), and IL\u201023 inhibitors (IL\u201023i), each compared with an independently matched nonbiologic psoriasis comparator cohort. Race stratified analyses were restricted to biologic\u2010treated patients, with White patients serving as the reference group. Psoriasis patients treated with biologics exhibited a 37% lower hazard of MACE compared with non\u2010biologic users over the 10\u2010year follow\u2010up period [2160 vs. 3294; HR 0.63 (0.60\u20130.67)]. Class\u2010specific analyses revealed reductions in MACE risk for TNFi [1403 vs. 1844; HR: 0.74 (0.69\u20130.80)], IL\u201017i [285 vs. 450; HR: 0.61 (0.53\u20130.72)], IL\u201012\/23i [280 vs. 374; HR: 0.73 (0.62\u20130.86)], and IL\u201023i [238 vs. 363; HR: 0.64 (0.54\u20130.76)]. Race stratified analyses showed broadly similar MACE risk across racial groups; although, patients identifying as Non\u2010White treated with TNFi did experience a reduced MACE risk compared to White patients [127 vs. 162; HR: 0.79 (0.62\u20130.99)]. This isolated finding should be interpreted cautiously given multiple race stratified comparisons. Overall, biologic therapy is associated with lower 10\u2010year MACE risk among patients with psoriasis, with findings observed across biologic classes and largely consistent across racial strata.<\/jats:p>","DOI":"10.1111\/1346-8138.70396","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:57:16Z","timestamp":1785131836000},"page":"1439-1447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Major Adverse Cardiovascular Event Across Diverse Racial Groups of Psoriasis Patients on Biologic Therapy: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3072-6732","authenticated-orcid":false,"given":"Chunghwan","family":"Ro","sequence":"first","affiliation":[{"name":"Department of Dermatology Eastern Virginia Medical School, Macon &amp; Joan Brock Virginia Health Sciences at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4995-841X","authenticated-orcid":false,"given":"Ana","family":"Ormaza Vera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eastern Virginia Medical School, Macon &amp; Joan Brock Virginia Health Sciences at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-7960","authenticated-orcid":false,"given":"Waleed","family":"Adawi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eastern Virginia Medical School, Macon &amp; Joan Brock Virginia Health Sciences at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-1904","authenticated-orcid":false,"given":"Clinton W.","family":"Enos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eastern Virginia Medical School, Macon &amp; Joan Brock Virginia Health Sciences at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.058"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.03.028"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00579"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15531"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.011199"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.055"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2589"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz009"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.03.024"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005285"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14964"},{"issue":"10","key":"e_1_2_13_15_1","first-page":"1002","article-title":"Evaluation of Risk of Major Adverse Cardiovascular Events With Biologic Therapy in Patients With Psoriasis","volume":"16","author":"Bissonnette R.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18232"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004591"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.12.025"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.03.055"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010015\u20100169\u2010x"},{"issue":"11","key":"e_1_2_13_21_1","first-page":"16","article-title":"Psoriasis in Skin of Color: Epidemiology, Genetics, Clinical Presentation, and Treatment Nuances","volume":"7","author":"Alexis A. 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