{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:55:26Z","timestamp":1791446126947,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cutaneous squamous cell carcinoma (cSCC) may develop in chronic inflammatory settings, but clinicopathological features and outcomes remain poorly defined. To characterize clinical features and disease\u2010specific survival (DSS) of cSCC arising from HS or EC in a single\u2010institution cohort, and to assess baseline neutrophil\u2010to\u2010lymphocyte ratio (NLR) as a readily available inflammatory marker. We retrospectively reviewed 231 patients with cSCC diagnosed at a tertiary academic center between January 2013 and December 2024. After excluding 36 without baseline NLR data, a total of 195 patients were analyzed. Clinical characteristics, tumor staging, HS severity, baseline NLR, and DSS were evaluated. Of 195 evaluable patients, 8 had cSCC arising from hidradenitis suppurativa (HS), 5 from epidermal cysts (EC), 14 from burn scars, and 168 de novo (primary) cSCC. HS\/EC\u2010associated cSCC showed significantly higher baseline NLR than others (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016). In univariate analysis, primary tumor site, clinical T and N stages, baseline NLR, and HS\/EC\u2010associated lesion were significantly associated with DSS. Burn scar\u2013associated cSCC was not significantly associated with DSS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.60). In multivariate analysis, clinical N and T stage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and HS\/EC\u2010associated cSCC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020; HR\u2009=\u20094.28, 95% CI, 1.26\u201314.6) remained independently associated with poorer DSS. In this cohort, cSCC arising from HS or EC was associated with elevated baseline NLR and poorer DSS. These findings suggest that HS\/EC\u2010associated cSCC may represent a clinically recognizable high\u2010risk subgroup warranting careful surveillance, while the prognostic role of baseline NLR requires validation in larger studies.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70433","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:58:13Z","timestamp":1785751093000},"page":"1515-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Squamous Cell Carcinoma Arising From Hidradenitis Suppurativa and Epidermal Cyst: Clinical Characteristics, Baseline Neutrophil\u2010To\u2010Lymphocyte Ratio, and Disease\u2010Specific Survival in a Retrospective Cohort"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-2786","authenticated-orcid":false,"given":"Yusuke","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5432-4368","authenticated-orcid":false,"given":"Airi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Miyagi 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