{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:55:06Z","timestamp":1791446106723,"version":"4.3.3"},"reference-count":5,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mucous membrane pemphigoid (MMP) primarily affects the mucosal surfaces with minimal skin involvement. Approximately 70% of MMP cases show positivity for anti\u2010BP180 antibodies. Paraneoplastic pemphigus (PNP) typically presents with antibodies against periplakin and envoplakin. We report a case of anti\u2010BP180\u2009MMP with a past history of maxillary carcinoma showing immunoblot positivity for 190\u2009kDa periplakin and 210\u2009kDa envoplakin. A 64\u2010year\u2010old man presented with recurrent oral erosions and later developed widespread mucocutaneous lesions. Histopathological examination revealed subepidermal blisters with mixed inflammatory cell infiltration. Direct and indirect immunofluorescence revealed immunoglobulin (Ig) G and C3 deposition in the basement membrane zone, and split\u2010skin indirect immunofluorescence revealed localized IgG in the epidermis. Immunoblotting revealed reactivity to the BP180 C\u2010terminal domain, periplakin, and envoplakin, whereas chemiluminescence enzyme immunoassay yielded negative results for Dsg1, Dsg3, and BP180. Enzyme\u2010linked immunosorbent assay showed positive for BP180 and BP230 antibodies. The lesions improved with the administration of topical steroids, oral minocycline, and nicotinamide. Although periplakin and envoplakin antibodies are characteristic of PNP, their persistence despite clinical improvement suggests nonpathogenicity in this case. The clinical course and disappearance of anti\u2010BP180 C\u2010terminal antibodies suggest pathogenicity. Maxillary carcinoma, a type of squamous cell carcinoma, may contribute to the generation of antiplakin autoantibodies.<\/jats:p>","DOI":"10.1111\/1346-8138.70439","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:03:37Z","timestamp":1785737017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010\n                    <scp>BP180<\/scp>\n                    Mucosal Membrane Pemphigoid With a History of Maxillary Carcinoma With Antibodies to 190\u2009\n                    <scp>kDa<\/scp>\n                    Periplakin and 210\u2009\n                    <scp>kDa<\/scp>\n                    Envoplakin: A Case Report"],"prefix":"10.1111","volume":"53","author":[{"given":"Mami","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Dermatology Kobe Ekisaikai Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ohata","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Jimbo","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-3255","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine, Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-711X","authenticated-orcid":false,"given":"Takeshi","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.12.402"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S100802"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.156"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03646.x"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01645.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:35:56Z","timestamp":1791444956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/1346-8138.70439"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70439","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}