{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:27:11Z","timestamp":1786598831655,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lichen sclerosus (LS) is a chronic inflammatory dermatosis of the anogenital region with limited therapeutic options. Emerging evidence implicates dysregulation of the Janus kinase (JAK)\u2013signal transducer and activator of transcription (STAT) pathway in LS pathogenesis, supporting investigation of targeted therapies. We report a series of 6 patients treated with topical ruxolitinib for vulvar LS, applied twice daily. Clinical outcomes were assessed using the Clinical Scoring System (CSS) and Patient Global Assessment (PtGA) over a mean follow\u2010up of 7.5\u2009months. All patients reported early symptomatic improvement in pruritus and burning. In parallel, PtGA scores showed significant improvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). No local or systemic adverse events were observed. These findings suggest that topical JAK\u2013STAT inhibition may represent a steroid\u2010sparing option for achieving symptomatic improvement in LS, particularly in patients with concomitant autoimmune conditions. Larger controlled studies are warranted to confirm these preliminary observations.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70460","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:33:25Z","timestamp":1786595605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Vulvar Lichen Sclerosus With Topical Ruxolitinib: A Single\u2010Center Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7769","authenticated-orcid":false,"given":"Alessia","family":"Paganelli","sequence":"first","affiliation":[{"name":"Center for Regenerative and Immunological Dermatology (CEDRI), IDI\u2010IRCCS Istituto Dermopatico Dell'immacolata  Rome Italy"},{"name":"Department of Life Sciences, Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Colonna","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Immunological Dermatology (CEDRI), IDI\u2010IRCCS Istituto Dermopatico Dell'immacolata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Didona","sequence":"additional","affiliation":[{"name":"Rare Diseases Unit IDI\u2010IRCCS Istituto Dermopatico Dell'immacolata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science University of La Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-2485","authenticated-orcid":false,"given":"Cristina","family":"Cristofoletti","sequence":"additional","affiliation":[{"name":"Clinical Trial Center IDI\u2010IRCCS Istituto Dermopatico Dell'immacolata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-6639","authenticated-orcid":false,"given":"Mauro","family":"Picardo","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Immunological Dermatology (CEDRI), IDI\u2010IRCCS Istituto Dermopatico Dell'immacolata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1106318"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102025\u2010266929"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0644"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14893"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20083"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14516"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094315"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.70354"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.06.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14434"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70095"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2025.08.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70042"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.7696"}],"container-title":["The 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