{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:31:45Z","timestamp":1793881905958,"version":"4.7.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\u20102314\u2010B\u2010006\u2010071"],"award-info":[{"award-number":["NSTC 114\u20102314\u2010B\u2010006\u2010071"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The optimal surgical margin for cutaneous melanoma remains controversial, particularly in anatomically constrained areas such as the acral regions. We conducted a retrospective cohort study of 79 patients with invasive cutaneous melanoma treated at National Cheng Kung University Hospital between 2012 and 2024, including 51 cases of acral lentiginous melanoma (ALM). Patients were categorized as having adequate surgical margins (per NCCN guidelines) or inadequate but histologically tumor\u2010free margins. Survival outcomes, including overall survival (OS), progression\u2010free survival (PFS), local recurrence\u2010free survival (LRFS), and melanoma\u2010specific survival (MSS), were analyzed using Kaplan\u2013Meier estimates and Cox proportional hazards models after a median follow\u2010up of 60\u2009months. No significant differences were observed in OS, LRFS, or MSS between the two groups. Although univariate analysis suggested a difference in PFS, the association did not persist in multivariate analysis, where margin inadequacy was not independently associated with poorer outcomes (OS: HR 1.81, 95% CI 0.84\u20133.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.13; PFS: HR 1.87, 95% CI 0.90\u20133.87,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.093). Subgroup analyses of ALM and high\u2010risk tumors (Breslow thickness\u2009&gt;\u20092\u2009mm) yielded consistent results, showing no significant differences in oncologic outcomes. In conclusion, our study showed that inadequate but histologically tumor\u2010free excision margins may not independently compromise survival outcomes in cutaneous melanoma. A narrower margin may be acceptable in selected patients when wider excision is precluded by anatomic or functional constraints.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70469","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:23Z","timestamp":1787066123000},"page":"1660-1670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Lateral Margin Adequacy on Survival in Cutaneous Melanoma: An Asian Retrospective Cohort Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1963-5968","authenticated-orcid":false,"given":"Chun\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Educational Center National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-2092","authenticated-orcid":false,"given":"Cheng\u2010Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Pathology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Chen","family":"Pan","sequence":"additional","affiliation":[{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Surgery, Section of Plastic and Reconstructive Surgery National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-7357","authenticated-orcid":false,"given":"Julia Yu\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-7339","authenticated-orcid":false,"given":"Tak\u2010Wah","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Biochemistry and Molecular Biology College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Center of Applied Nanomedicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-2542","authenticated-orcid":false,"given":"Yi\u2010Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-2094","authenticated-orcid":false,"given":"Yi\u2010Hsuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Oncology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi\u2010Huei","family":"Lu","sequence":"additional","affiliation":[{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Division of Nuclear Medicine, Department of Medical Imaging National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H. W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Oncology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Radiation Oncology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Clinical Medicine College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-9486","authenticated-orcid":false,"given":"Wei\u2010Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Skin Cancer Team National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0500-9"},{"key":"e_1_2_10_3_1","unstructured":"National Comprehensive Cancer Network \u201cNCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Melanoma: Cutaneous\u201d(2025) 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and Skin Cancer Trials Ltd \u201cMelanoma Margins Trial\u2010II: 1 cm v 2 cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT\u2010II) \u201dClinicalTrials.gov (2019) updated November 27 2024 https:\/\/clinicaltrials.gov\/study\/NCT03860883."}],"container-title":["The Journal of 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