{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:20:21Z","timestamp":1787635221558,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16233"],"award-info":[{"award-number":["21K16233"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17806"],"award-info":[{"award-number":["19K17806"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K16774"],"award-info":[{"award-number":["23K16774"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008731","name":"Nakatomi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging is associated with thinning of the epidermis and dermis, leading to wrinkles, dryness, and impaired skin barrier function. Sirtuin\u20101 (SIRT1) is an NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent protein deacetylase that suppresses cellular senescence and matrix metalloproteinase (MMP) expression, both of which contribute to skin thinning. Here, we investigated whether dietary resveratrol (RSV), a SIRT1 activator, mitigates age\u2010related skin thinning in mice. Epidermal and dermal thicknesses were significantly reduced in 60\u2010week\u2010old (wo) mice compared with 20\u2010wo mice, and these changes were attenuated by RSV administration (0.4\u2009g\/kg diet) from 28\u2009weeks of age for 32\u2009weeks. In the epidermis, the number of Ki67\u2010positive cells decreased in aged mice but was restored by RSV treatment. Although RSV did not alter the number of SIRT1\u2010positive cells, it significantly reduced the number of acetyl\u2010lysine\u2013positive cells, indicating enhanced SIRT1 activity. In the dermis, the immunopositive areas of MMP\u20109 and MMP\u201013 increased in aged mice, and these age\u2010associated increases were not observed in RSV\u2010treated aged mice. Phosphorylated SMAD2 levels decreased with age but were not affected by RSV. Furthermore, SIRT1 knockdown in human HaCaT keratinocytes increased p21 expression and senescence\u2010associated \u03b2\u2010galactosidase activity. Taken together, these findings suggest that the SIRT1 activator RSV ameliorates age\u2010related skin thinning by suppressing cellular senescence in the epidermis and inhibiting dermal collagen degradation.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70471","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:03:17Z","timestamp":1787634197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SIRT1<\/scp>\n                    Activator Resveratrol Attenuates Age\u2010Related Skin Thinning in Mice"],"prefix":"10.1111","author":[{"given":"Fuka","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyori","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Kunimoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Hosoda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-7167","authenticated-orcid":false,"given":"Kouhei","family":"Horimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6873-1297","authenticated-orcid":false,"given":"Atsushi","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sapporo Medical University School of Medicine  Sapporo 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