{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:05Z","timestamp":1788412565208,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21J12334"],"award-info":[{"award-number":["21J12334"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K18287"],"award-info":[{"award-number":["21K18287"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K19209"],"award-info":[{"award-number":["23K19209"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H00547"],"award-info":[{"award-number":["23H00547"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR205H"],"award-info":[{"award-number":["JPMJFR205H"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hard\u2010to\u2010heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence\u2010associated mechanisms, including stress\u2010responsive p53\/p21 signaling and senescence\u2010associated secretory phenotype\u2010related inflammation, contribute to impaired wound repair. We investigated whether local low\u2010frequency vibration modulates wound healing and senescence\u2010associated markers in tissues and exudates in a hyperglycemic rat full\u2010thickness wound model, and whether treatment frequency affects its efficacy. A full\u2010thickness wound model was established in hyperglycemic rats and local low\u2010frequency vibration at 52\u2009Hz was applied once or twice daily for 40\u2009min (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095). The relative wound area was monitored, and molecular and histological analyses were performed on tissue samples and exudates to evaluate cellular senescence and the senescence\u2010associated secretory phenotype. Local low\u2010frequency vibration application twice daily significantly accelerated wound closure compared with that observed in the control group. Molecular and histological analyses revealed a reduction in the number of PTX3\u2010positive cells and p53 expression in the twice\u2010daily treatment group. Senescence\u2010associated genes related to p53\/p21 signaling, including\n                    <jats:italic>Cdkn1a<\/jats:italic>\n                    and\n                    <jats:italic>Rb1<\/jats:italic>\n                    , were downregulated in tissues and exudates. The number of p53\u2010positive cells in exudate was lower in the twice\u2010daily treatment group. In conclusion, local low\u2010frequency vibrations enhanced wound healing and reduced the expression of senescence\u2010associated markers and inflammatory mediators in tissues and exudates. These findings suggest that local low\u2010frequency vibrations may act as a noninvasive, senomorphic physical therapy that modulates senescence\u2010related pathways and inflammation, although future studies should determine whether local low\u2010frequency vibrations further modulate senescence pathways.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70486","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:29:09Z","timestamp":1788409749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Low\u2010Frequency Vibration Enhances Wound\u2010Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-0952","authenticated-orcid":false,"given":"Daijiro","family":"Haba","sequence":"first","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Well\u2010Being Nursing, Graduate School of Nursing Ishikawa Prefectural Nursing University  Kahoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-5107","authenticated-orcid":false,"given":"Chihiro","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-3523","authenticated-orcid":false,"given":"Qi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Research, Cizik School of Nursing The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanai","family":"Tomida","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Next\u2010Generation Wound Care Innovation, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8612-1484","authenticated-orcid":false,"given":"Ai","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-1251","authenticated-orcid":false,"given":"Hiromi","family":"Sanada","sequence":"additional","affiliation":[{"name":"Ishikawa Prefectural Nursing University  Kahoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-2464","authenticated-orcid":false,"given":"Gojiro","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the Treatment of Chronic Wounds","volume":"4","author":"Frykberg R. G.","year":"2015","journal-title":"Advances in Wound Care"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjon.2020.29.5.S6","article-title":"Hard\u2010To\u2010Heal Wounds, Biofilm and Wound Healing: An Intricate Interrelationship","volume":"29","author":"Azevedo M. M.","year":"2020","journal-title":"British Journal of Nursing"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong D. G.","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-021769","article-title":"Cohort Study Evaluating Pressure Ulcer Management in Clinical Practice in the UK Following Initial Presentation in the Community: Costs and Outcomes","volume":"8","author":"Guest J. F.","year":"2018","journal-title":"BMJ Open"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3269","article-title":"Guidelines on the Prevention of Foot Ulcers in Persons With Diabetes (IWGDF 2019 Update)","volume":"36","author":"Bus S. A.","year":"2020","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in Health and Disease","volume":"169","author":"He S.","year":"2017","journal-title":"Cell"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00773","article-title":"Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds","volume":"8","author":"Wilkinson H. 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J.","year":"2011","journal-title":"Expert Review of Molecular Medicine"},{"issue":"7","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jid.2024.10.609","article-title":"Fibroblast\u2010Mediated Macrophage Recruitment Supports Acute Wound Healing","volume":"145","author":"Amuso V. M.","year":"2025","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An Essential Role for Senescent Cells in Optimal Wound Healing Through Secretion of PDGF\u2010AA","volume":"31","author":"Demaria M.","year":"2014","journal-title":"Developmental Cell"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:29:13Z","timestamp":1788409753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":31,"alternative-id":["10.1111\/1346-8138.70486"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70486","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70486"}}