{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:03:20Z","timestamp":1789959800628,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this study, PU and normal tissues were collected from 24 patients with PU. An exploratory Olink Inflammation Panel analysis was performed to identify candidate differentially expressed proteins (DEPs) between PU and normal tissue samples from 16 of the 24 patients with PU. A total of 16 candidate DEPs were identified using an unadjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 threshold between the two groups. Among them, CCL17 had the largest fold change and diagnostic potential with an optimal AUC value (0.75). In addition, CCL17, ANGPT1, FASLG, and VEGFA demonstrated high clinical relevance in the patients with PU. Immunohistochemistry and western blotting using PU tissues obtained from the remaining 8 patients confirmed the decreased expression of CCL17 in PU tissues. In conclusion, CCL17 is a novel potential biomarker for PU pathogenesis and prognosis.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70492","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:49:15Z","timestamp":1789958955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue Olink Proteomics Analysis Reveals\n                    <scp>CCL17<\/scp>\n                    as a Potential Biomarker in Patients With Pressure Ulcers"],"prefix":"10.1111","author":[{"given":"Linjun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Wound Repair Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0297-5238","authenticated-orcid":false,"given":"Shihan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqin","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0696-5597","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Wound Repair Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Wound Repair Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0358-6380","authenticated-orcid":false,"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nursing Department Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Hangzhou Geriatric Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-0959","authenticated-orcid":false,"given":"Yongke","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Hangzhou Geriatric Hospital  Hangzhou China"},{"name":"Department of Rehabilitation Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1553\u20107250(15)41034\u20107"},{"key":"e_1_2_11_3_1","unstructured":"Merriam\u2010Webster Dictionary (2016) accessed March 15 2016 http:\/\/www.merriam\u2010webster.com\/dictionary\/ulcer."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ip.2003.003715"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1995.31"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.06.202"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12824"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12798"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2021.100149"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c07103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"W.Zhong F.Edfors A.Gummesson et\u00a0al. \u201cNext Generation Plasma Proteome Profiling to Monitor Health and Disease. 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