{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:53Z","timestamp":1789794173580,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic spontaneous urticaria (CSU) is monitored mainly with patient\u2010reported outcomes, whereas objective biomarkers that reflect disease status remain limited. This prospective observational cohort study included 55 adults with antihistamine\u2010refractory CSU who initiated omalizumab as part of routine clinical care and 30 healthy controls for baseline oxidative stress comparisons. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured at baseline and month 6, and at month 12 in patients requiring treatment escalation. Disease control, disease activity, and quality of life were assessed using validated instruments. Unadjusted baseline TOS and OSI were lower in patients than in controls, but these differences were attenuated and were no longer statistically significant after adjustment for age, sex, and BMI (log\u2010TOS:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.297,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.115; log\u2010OSI:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.310,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.102). Month\u20106 OSI was higher in uncontrolled than controlled patients [0.274 (0.162\u20130.382) vs. 0.135 (0.100\u20130.245) AU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010] and remained associated with uncontrolled disease after adjustment for baseline OSI, BMI, CRP, total IgE, and angioedema presence (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.572,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.030). Within\u2010person change in OSI correlated inversely with change in UCT (rho\u2009=\u2009\u22120.596,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas its association with change in CU\u2010Q2oL did not reach statistical significance (rho\u2009=\u20090.264,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.053). In the 15\u2010patient escalation subgroup, OSI did not change significantly over time (Friedman\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.074). These exploratory findings indicate that on\u2010treatment OSI was associated with concurrent disease control and that within\u2010person OSI change paralleled change in UCT. Incremental value beyond validated patient\u2010reported outcomes, predictive performance, and treatment\u2010guiding value was not established.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70504","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:48:17Z","timestamp":1789793297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Oxidative Stress Index With Disease Control During Omalizumab\u2010Based Treatment in Antihistamine\u2010Refractory Chronic Spontaneous Urticaria: A Prospective Observational Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-2113","authenticated-orcid":false,"given":"K\u00fcbra","family":"A\u015f\u0131k\u2010Cans\u0131z","sequence":"first","affiliation":[{"name":"Department of Immunology and Allergy Diseases Yalova Training and Research Hospital  Yalova Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-9098","authenticated-orcid":false,"given":"Nurhan Aliye","family":"Sayaca","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy Diseases Bursa City Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-2139","authenticated-orcid":false,"given":"Eylem","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy Diseases \u0130zmir Tepecik Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-4593","authenticated-orcid":false,"given":"Beyhan Cengiz","family":"\u00d6zyurt","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Manisa Celal Bayar University  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-6346","authenticated-orcid":false,"given":"Ece","family":"Onur","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Manisa Celal Bayar University  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-2163","authenticated-orcid":false,"given":"Serkan","family":"Erdal","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Mersin Anamur State Hospital  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-3363","authenticated-orcid":false,"given":"Talat","family":"Ecemi\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Manisa Celal Bayar University  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-1681","authenticated-orcid":false,"given":"Cengiz","family":"K\u0131rmaz","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy Diseases, Faculty of Medicine Manisa Celal Bayar University  Manisa 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