{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:51:00Z","timestamp":1791597060406,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors are widely used for diabetes treatment. However, reports of DPP\u20104 inhibitor\u2010associated bullous pemphigoid (BP) have been increasing. This study examined 12 cases of BP with oral mucosal lesions associated with DPP\u20104 inhibitor therapy. Six cases presented with only oral mucosal lesions, while the other six patients had non\u2010inflammatory skin lesions. Discontinuation of DPP\u20104 inhibitors led to symptom improvement in nine cases, whereas three cases did not improve, with lesion progression to the pharynx. Remission was achieved after a mean of 20.8\u2009\u00b1\u200924.6\u2009months after DPP\u20104 inhibitor discontinuation, but two cases relapsed. Anti\u2010BP180 NC16a antibodies were positive in six cases, while full\u2010length BP180 ELISA was positive in 8 of 10 tested cases. These findings suggested that DPP\u20104 inhibitor\u2010associated BP frequently involves oral mucosal lesions, and some cases may present solely with mucosal symptoms. Given the potential for recurrence and severe progression, long\u2010term follow\u2010up is essential.<\/jats:p>","DOI":"10.1111\/1346-8138.70507","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:25:12Z","timestamp":1791595512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Study of Bullous Pemphigoid With Oral Mucosal Symptoms After Oral Administration of Dipeptidyl Peptidase\u20104 Inhibitors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2399-604X","authenticated-orcid":false,"given":"Yuria","family":"Akira","sequence":"first","affiliation":[{"name":"Department of Oral Oncology, Oral and Maxillofacial Surgery Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-0832","authenticated-orcid":false,"given":"Masaki","family":"Minabe","sequence":"additional","affiliation":[{"name":"Department of Oral Oncology, Oral and Maxillofacial Surgery Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Oral Oncology, Oral and Maxillofacial Surgery Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6504-9448","authenticated-orcid":false,"given":"Junichiro","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Oral Oncology, Oral and Maxillofacial Surgery Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Hospital Dentistry Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-9644","authenticated-orcid":false,"given":"Kentaro","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6191-5755","authenticated-orcid":false,"given":"Takeshi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Oral Oncology, Oral and Maxillofacial Surgery Tokyo Dental College  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-7107","authenticated-orcid":false,"given":"Michiyoshi","family":"Kouno","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare, Ichikawa General Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"823","article-title":"Burden of Disease of BP: A Targeted Literature Review","volume":"240","author":"Bahloul D.","year":"2024","journal-title":"Dermatology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4239\/wjd.v12.i9.1426","article-title":"Dipeptidyl Peptidase\u20104 Inhibitor\u2010Induced Autoimmune Diseases: Current Evidence","volume":"12","author":"Roy A.","year":"2021","journal-title":"World Journal of Diabetes"},{"issue":"3","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaad.2011.06.032","article-title":"Definitions and Outcome Measures for Bullous Pemphigoid: Recommendations by an International Panel of Experts","volume":"66","author":"Murrell D. F.","year":"2012","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jcpt.12397","article-title":"Dipeptidyl Peptidase\u2010IV Inhibitors Induced BP: A Case Report and Analysis of Cases Reported in the European Pharmacovigilance Database","volume":"41","author":"Garc\u00eda M.","year":"2016","journal-title":"Journal of Clinical Pharmacy and Therapeutics"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20100210"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.jid.2016.06.622","article-title":"Autoantibody Profile Differentiates Between Inflammatory and Noninflammatory BP","volume":"136","author":"Izumi K.","year":"2016","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.680871"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842\u2010024\u201000165\u2010w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv9423"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.2741\/2785","article-title":"Dipeptidyl Peptidase IV (DPP IV\/CD26) is a Cell\u2010Surface Plasminogen Receptor","volume":"13","author":"Gonzalez\u2010Gronow M.","year":"2008","journal-title":"Frontiers in Bioscience"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01752"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jid.2017.11.023","article-title":"HLA\u2010DQB1*03:01 as a Biomarker for Genetic Susceptibility to BP Induced by DPP\u20104 Inhibitors","volume":"138","author":"Ujiie H.","year":"2018","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1046\/j.1365-2133.2001.04448.x","article-title":"HLA\u2010DQB1 Alleles in Italian Patients With Mucous Membrane Pemphigoid Predominantly Affecting the Oral Cavity","volume":"145","author":"Carrozzo M.","year":"2001","journal-title":"British Journal of Dermatology"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:25:19Z","timestamp":1791595519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":13,"alternative-id":["10.1111\/1346-8138.70507"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70507","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"2026-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70507"}}