{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:05:14Z","timestamp":1790060714019,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2022RY8549_002"],"award-info":[{"award-number":["2022RY8549_002"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["J53D23003260006"],"award-info":[{"award-number":["J53D23003260006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lentigo maligna (LM) and LM melanoma (LMM) predominantly arise on chronically sun\u2010damaged head and neck skin and are often considered biologically uniform across facial locations. Whether invasive potential varies by anatomical subsite remains unclear. We aimed to evaluate the association between predefined head and neck subsites and invasive phenotype in LM and LMM. In this retrospective cohort study, 134 patients with histopathologically confirmed LM and LMM were analyzed. Head and neck lesions were stratified a priori into scalp, nose, ear, periocular region, other facial areas, and neck. Multivariable linear and logistic regression models assessed associations between anatomical subsite, Breslow thickness, and invasive disease, adjusting for age and sex. Among 118 head and neck lesions, 50% were invasive. Anatomical subsite was independently associated with invasive disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0025), with auricular lesions demonstrating the highest frequency of invasion and nasal and periocular lesions showing significantly lower odds. Among invasive LMM, nasal lesions also demonstrated significantly lower Breslow thickness compared with auricular lesions in adjusted analysis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026). To conclude, head and neck LM and LMM demonstrated significant anatomical differences in invasive presentation. These findings suggest that anatomical subsite may influence the likelihood of invasive disease and support greater anatomical consideration during clinical evaluation.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70513","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:19:11Z","timestamp":1790057951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Anatomical Subsite and Invasive Disease in Head and Neck Lentigo Maligna and Lentigo Maligna Melanoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-2861","authenticated-orcid":false,"given":"Emi","family":"Dika","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"Oncologic Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Schiavo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-4353","authenticated-orcid":false,"given":"Elisabetta","family":"Magnaterra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"Oncologic Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2550-4630","authenticated-orcid":false,"given":"Leonardo","family":"Veneziano","sequence":"additional","affiliation":[{"name":"Oncologic Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Maria","family":"Cama","sequence":"additional","affiliation":[{"name":"Oncologic Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Tassone","sequence":"additional","affiliation":[{"name":"Plastic Surgery IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-4172","authenticated-orcid":false,"given":"Federico","family":"Venturi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"Oncologic Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jaad.2024.09.065","article-title":"Lentigo Maligna Part I: Epidemiology, Risk Factors, and Diagnosis","volume":"93","author":"Gupta S.","year":"2025","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/ced\/llad394","article-title":"Lentigo Maligna: A Review","volume":"49","author":"Karponis D.","year":"2024","journal-title":"Clinical and Experimental Dermatology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jaad.2023.07.008","article-title":"Histologic Margin Status Is a Predictor of Relapse in Lentigo Maligna Melanoma","volume":"89","author":"Hoang M. P.","year":"2023","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jamadermatol.2019.0467","article-title":"Histologic Features Associated With an Invasive Component in Lentigo Maligna Lesions","volume":"155","author":"Moreno A.","year":"2019","journal-title":"JAMA Dermatology"},{"key":"e_1_2_11_6_1","first-page":"223","article-title":"Folliculotropism in Head and Neck Lentigo Maligna and Lentigo Maligna Melanoma","volume":"19","author":"Dika E.","year":"2021","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/1097-0142(19880815)62:4<831::AID-CNCR2820620432>3.0.CO;2-X","article-title":"Prognostic Factors in Head and Neck Melanoma. Effect of Lesion Location","volume":"62","author":"Wanebo H. J.","year":"1988","journal-title":"Cancer"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3390\/cancers16091688","article-title":"Association of miR\u2010146a\u20105p and miR\u201021\u20105p With Prognostic Features in Melanomas","volume":"16","author":"Naddeo M.","year":"2024","journal-title":"Cancers"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.3390\/ijms23115911","article-title":"Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis","volume":"23","author":"Ricci C.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15188","article-title":"Lentigo Maligna and Lentigo Maligna Melanoma of the External Ear: Clinical and Dermoscopic Features of 19 Patients","volume":"33","author":"Dika E.","year":"2024","journal-title":"Experimental Dermatology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.amjoto.2017.01.032","article-title":"Melanoma of the External Ear: A Population\u2010Based Study","volume":"38","author":"Deep N. L.","year":"2017","journal-title":"American Journal of Otolaryngology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1470-2045(05)70208-4","article-title":"Tumours of the External Ear and Temporal Bone","volume":"6","author":"Devaney K. O.","year":"2005","journal-title":"Lancet Oncology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics14080800","article-title":"Molecular Characterization of Advanced\u2010Stage Melanomas in Clinical Practice Using a Laboratory\u2010Developed Next\u2010Generation Sequencing Panel","volume":"14","author":"Maloberti T.","year":"2024","journal-title":"Diagnostics"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/lary.23563","article-title":"The Importance of Ulceration of Cutaneous Melanoma of the Head and Neck: A Comparison of Ear (Pinna) and Nonear Sites","volume":"122","author":"Augenstein A. C.","year":"2012","journal-title":"Laryngoscope"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14202"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:19:13Z","timestamp":1790057953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":14,"alternative-id":["10.1111\/1346-8138.70513"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70513","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2026-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70513"}}