{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:01Z","timestamp":1790661781950,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016730","name":"Torii Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Molluscum contagiosum (MC) is a common viral skin infection in children. In the two Phase 3 Cantharidin Application in Molluscum Patients [CAMP\u20101 and CAMP\u20102] studies, cantharidin, a drug\u2010device combination containing cantharidin (0.7%), a topical vesicant, was significantly superior to placebo in achieving complete clearance of MC lesions at the end of the study. The aim of this study was to evaluate the efficacy and safety of TO\u2010208, a drug\u2010device combination containing 0.7% w\/v cantharidin, compared with a placebo in patients with MC in Japan. In this Phase 3, double\u2010blind study, patients aged \u2265\u20092\u2009years with \u2265\u20095 MC lesions at baseline were randomly assigned (1:1 ratio) to the TO\u2010208 group or placebo group, with up to 4 applications every 21\u2009days. The primary efficacy endpoint was the proportion of subjects with complete MC lesion clearance (baseline and new) at Day 85. The full analysis set was conducted for the efficacy population. The secondary efficacy outcome was the percentage change from baseline in the total number of MC lesions, including both baseline and newly developed lesions. The safety endpoints were adverse events and local skin reactions. In total, 148 subjects received TO\u2010208 and 155 received placebo. The proportion of subjects achieving complete clearance at Day 85 was significantly higher with TO\u2010208 compared to placebo 50.0% versus 23.2% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The percentage change in MC lesions from baseline to Day 85 was \u221288.35% versus \u221244.57% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Commonly reported adverse events with TO\u2010208 were mild or moderate blistering, pruritus, pain, and erythema at the application site. Overall, TO\u2010208 was significantly superior to the placebo in achieving complete clearance of MC lesions at the end of the study visit and was generally well tolerated, with adverse events that were predominantly mild to moderate in severity and limited to application sites.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Japan Registry of Clinical Trials: jRCT2041220039\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70517","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:31:52Z","timestamp":1790659912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Efficacy and Safety of\n                    <scp>TO<\/scp>\n                    \u2010208 in Patients 2\u2009Years of Age or Older With Molluscum Contagiosum in Japan: A Randomized, Double\u2010Blind, Placebo\u2010Controlled, Phase 3 Study (208\u20103\u20101) and Its Open\u2010Label Extension"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6425-2392","authenticated-orcid":false,"given":"Takafumi","family":"Kadono","sequence":"first","affiliation":[{"name":"Department of Dermatology St. Marianna University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-0201","authenticated-orcid":false,"given":"Tsuyoshi","family":"Mitsuishi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Japanese Red Cross Saitama Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-079X","authenticated-orcid":false,"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-2879","authenticated-orcid":false,"given":"Yasushi","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-3993","authenticated-orcid":false,"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aichi Medical University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8991-132X","authenticated-orcid":false,"given":"Shinya","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Torii Pharmaceutical co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Ishiwata","sequence":"additional","affiliation":[{"name":"Torii Pharmaceutical co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-1357","authenticated-orcid":false,"given":"Thomas F.","family":"Haws","sequence":"additional","affiliation":[{"name":"Verrica Pharmaceuticals Inc.  West Chester Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cutler","sequence":"additional","affiliation":[{"name":"Verrica Pharmaceuticals Inc.  West Chester Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-3187","authenticated-orcid":false,"given":"Atsuyuki","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Igarashi Dermatological Clinic Higashi\u2010Gotanda  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(13)70109\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmt075"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2014.11.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.17157"},{"key":"e_1_2_11_6_1","volume-title":"StatPearls","author":"Badri T.","year":"2023"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"27","article-title":"Topical Cantharidin in the Management of Molluscum Contagiosum: Preliminary Assessment of an Ether\u2010Free, Pharmaceutical\u2010Grade Formulation","volume":"12","author":"Del Rosso J. F.","year":"2019","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.3238"},{"issue":"10","key":"e_1_2_11_10_1","first-page":"42","article-title":"Safety and Efficacy of VP\u2010102 (Cantharidin, 0.7% w\/v) in Molluscum Contagiosum by Body Region: Post Hoc Pooled Analyses From Two Phase III Randomized Trials","volume":"14","author":"Eichenfield L. F.","year":"2021","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010020\u201000570\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_11_13_1","first-page":"1","article-title":"Cantharidin on the Face? Yes, It Is Safe! A Retrospective Case Series on the Treatment of Pediatric Facial Molluscum Contagiosum","volume":"32","author":"Jahnke M. D.","year":"2015","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12276"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.2006.00313.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808326085"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:31:59Z","timestamp":1790659919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":15,"alternative-id":["10.1111\/1346-8138.70517"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70517","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70517"}}