{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:48:59Z","timestamp":1791856139817,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a case of epidermolysis bullosa acquisita (EBA) in a 47\u2010year\u2010old man who suffered for more than 10\u2009years. To evaluate the longitudinal immunological changes, we measured serum levels of anti\u2010basement membrane zone (BMZ) IgG antibodies by indirect immunofluorescence and anti\u2010type VII collagen antibodies by enzyme\u2010linked immunosorbent assay throughout the clinical course. In addition, serum concentrations of B\u2010cell activating factor (BAFF), interleukin (IL)\u20109, and IL\u201010 were measured. Titers of anti\u2010BMZ antibodies and anti\u2010type VII collagen antibodies fluctuated during the follow\u2010up period and corresponded broadly with clinical disease activity. Serum BAFF levels increased before the marked elevation of anti\u2010type VII collagen antibody titers, although they did not closely parallel disease activity. Serum IL\u20109 showed a transient peak around the time when the anti\u2010type VII collagen antibody titer reached its maximum. Serum IL\u201010 increased after the peak of the anti\u2010type VII collagen antibody titer. These temporal changes in BAFF, IL\u20109, and IL\u201010 observed may provide useful information for understanding the immunological phases of EBA.<\/jats:p>","DOI":"10.1111\/1346-8138.70519","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:27:35Z","timestamp":1791854855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Follow\u2010Up of Epidermolysis Bullosa Acquisita with Fluctuations in Serum Cytokine Levels: A Case Report"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7635-0818","authenticated-orcid":false,"given":"Masayuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-1947","authenticated-orcid":false,"given":"Koji","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-6698","authenticated-orcid":false,"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1803","authenticated-orcid":false,"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archderm.1971.04000130003001","article-title":"Epidermolysis Bullosa Acquisita: Report of Three Cases and Review of All Published Cases","volume":"103","author":"Roenigk H. H.","year":"1971","journal-title":"Archives of Dermatology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/JID.2015.356","article-title":"Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options","volume":"136","author":"Kasperkiewicz M.","year":"2016","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2018.00362","article-title":"Epidermolysis Bullosa Acquisita: The 2019 Update","volume":"5","author":"Koga H.","year":"2019","journal-title":"Frontiers in Medicine"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102736","article-title":"B Cell Activating Factor (BAFF): Structure, Functions, Autoimmunity and Clinical Implications in Systemic Lupus Erythematosus","volume":"20","author":"Moeckel T.","year":"2021","journal-title":"Autoimmunity Reviews"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41590-018-0177-0","article-title":"IL\u20109 Receptor Signaling in Memory B Cells Regulates Humoral Recall Responses","volume":"19","author":"Takatsuki S.","year":"2018","journal-title":"Nature Immunology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdermsci.2006.12.008","article-title":"Increased Serum Levels of a Proliferation\u2010Inducing Ligand in Patients with Bullous Pemphigoid","volume":"46","author":"Watanabe R.","year":"2007","journal-title":"Journal of Dermatological Science"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/exd.13459","article-title":"Biomarkers Related to Bullous Pemphigoid Activity and Outcome","volume":"26","author":"Giusti D.","year":"2017","journal-title":"Experimental Dermatology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12285634","article-title":"Development of an ELISA for Rapid Detection of Anti\u2010Type VII Collagen Autoantibodies in Epidermolysis Bullosa Acquisita","volume":"108","author":"Chen M.","year":"1997","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_8_10_1","first-page":"e224","article-title":"Serum Levels of Anti\u2010Type VII Collagen Antibodies Detected by Enzyme\u2010Linked Immunosorbent Assay in Patients With Epidermolysis Bullosa Acquisita Are Correlated With the Severity of Skin Lesions","volume":"27","author":"Kim J. H.","year":"2013","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1177\/09612033211028653","article-title":"10\u2009Years of Belimumab Experience: What Have We Learnt?","volume":"30","author":"Levy R. A.","year":"2021","journal-title":"Lupus"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2133.2006.07305.x","article-title":"Serum Levels of BAFF Are Increased in Bullous Pemphigoid but Not in Pemphigus Vulgaris","volume":"155","author":"Asashima N.","year":"2006","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_8_13_1","first-page":"2706","article-title":"Association of Serum B\u2010Cell Activating Factor Level and Proportion of Memory and Transitional B Cells with Clinical Response After Rituximab Treatment of Bullous Pemphigoid Patients","volume":"133","author":"Hall R. P.","year":"2013","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1135002","article-title":"Elevated Levels of Interleukin\u20109 in the Serum of Bullous Pemphigoid: Possible Association With the Pathogenicity of Bullous Pemphigoid","volume":"14","author":"Koga H.","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.autrev.2019.03.009","article-title":"Serum and Blister Fluid Levels of Cytokines and Chemokines in Pemphigus and Bullous Pemphigoid","volume":"18","author":"Kowalski E. H.","year":"2019","journal-title":"Autoimmunity Reviews"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:27:38Z","timestamp":1791854858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":14,"alternative-id":["10.1111\/1346-8138.70519"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70519","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70519"}}