{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:17Z","timestamp":1790733377649,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cutaneous angiosarcoma (cAS) is an aggressive vascular malignancy comprising idiopathic primary cutaneous angiosarcoma (PCAS) and secondary cutaneous angiosarcoma (SCAS) arising after radiation therapy or chronic lymphedema. Comparative genomic analyses delineating these subtypes in Asian populations remain limited. We retrospectively evaluated 15 Japanese cAS patients (10 PCAS, 5 SCAS) who underwent comprehensive genomic profiling (CGP) using FoundationOne CDx or liquid CDx between 2020 and 2026. Variants of unknown significance (VUS) and potential clonal hematopoiesis (CH)\u2010derived mutations were systematically excluded. The cohort demonstrated a uniformly low tumor mutational burden (median 4 mut\/Mb) with no MSI\u2010H cases.\n                    <jats:italic>TP53<\/jats:italic>\n                    was the most frequent driver mutation (47%), followed by\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    (33%),\n                    <jats:italic>MYC<\/jats:italic>\n                    (33%),\n                    <jats:italic>KDR<\/jats:italic>\n                    (27%),\n                    <jats:italic>CDKN2B<\/jats:italic>\n                    (27%),\n                    <jats:italic>MTAP<\/jats:italic>\n                    (27%),\n                    <jats:italic>KIT<\/jats:italic>\n                    (27%), and\n                    <jats:italic>PDGFRA<\/jats:italic>\n                    (27%). A molecular separation was observed between the two clinical subtypes, where focal\n                    <jats:italic>MYC<\/jats:italic>\n                    amplification was confined to SCAS cases (5\/5, 100%), whereas PCAS lesions were enriched with cell\u2010cycle pathway alterations via co\u2010deletions of\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    ,\n                    <jats:italic>CDKN2B<\/jats:italic>\n                    , and\n                    <jats:italic>MTAP<\/jats:italic>\n                    , alongside variable receptor tyrosine kinase (RTK) gains (\n                    <jats:italic>KIT\/PDGFRA<\/jats:italic>\n                    ). RAS pathway mutations presented only as three cases of missense variants across both subtypes. Although limited by sample size, these findings suggest subtype\u2010associated genomic patterns in Japanese cAS and may serve as preliminary observations that warrant validation in larger East Asian cohorts.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70520","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:29:46Z","timestamp":1790731786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Landscape of Primary and Secondary Cutaneous Angiosarcoma: A Single\u2010Center Retrospective Cohort Analysis in Japan"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-9486","authenticated-orcid":false,"given":"Wei\u2010Ting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-1732","authenticated-orcid":false,"given":"Harutaka","family":"Seshimo","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuto","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1566-1274","authenticated-orcid":false,"given":"Michitoshi","family":"Kurisaki","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikako","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6792-2372","authenticated-orcid":false,"given":"Misaki","family":"Kase","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kage","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-8182","authenticated-orcid":false,"given":"Eiji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-7346","authenticated-orcid":false,"given":"Kenjiro","family":"Namikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/jjco\/hyaf071","article-title":"A Review of Cutaneous Angiosarcoma: Epidemiology, Diagnosis, Prognosis, and Treatment Options","volume":"55","author":"Yamakawa K.","year":"2025","journal-title":"Japanese Journal of Clinical Oncology"},{"issue":"2","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41591-019-0749-z","article-title":"The Angiosarcoma Project: Enabling Genomic and Clinical Discoveries in a Rare Cancer Through Patient\u2010Partnered Research","volume":"26","author":"Painter C. A.","year":"2020","journal-title":"Nature Medicine"},{"issue":"22","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17223663","article-title":"Genomic and Demographic Characteristics of Angiosarcoma as Described in the AACR Project GENIE Registry","volume":"17","author":"Leach E.","year":"2025","journal-title":"Cancers"},{"issue":"11","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.18632\/oncotarget.24273","article-title":"Mutational Landscape of Radiation\u2010Associated Angiosarcoma of the Breast","volume":"9","author":"Thibodeau B. J.","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/path.6137","article-title":"Distinct Genomic Landscapes in Radiation\u2010Associated Angiosarcoma Compared With Other Radiation\u2010Associated Sarcoma Histologies","volume":"260","author":"Dermawan J. K.","year":"2023","journal-title":"Journal of Pathology"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1111\/1346-8138.70043","article-title":"Response to Crizotinib in ROS1 Fusion\u2010Positive Metastatic Angiosarcoma of the Scalp: A Case Report","volume":"53","author":"Nakayama Y.","year":"2026","journal-title":"Journal of Dermatology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jdin.2026.01.012","article-title":"Clinical Utility of Comprehensive Genomic Profiling in 175 Japanese Patients With Advanced Skin Malignancies Refractory to Standard Therapies","volume":"25","author":"Kambayashi Y.","year":"2026","journal-title":"JAAD International"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.70520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.70520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:29:47Z","timestamp":1790731787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.70520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":7,"alternative-id":["10.1111\/1346-8138.70520"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.70520","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1346-8138.70520"}}