{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:48:55Z","timestamp":1791856135034,"version":"4.3.4"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial blistering disorder of mucosal surfaces that can cause irreversible scarring, blindness, or dysphagia. Early diagnosis is challenging because histopathology is nonspecific and conventional BP180 NC16A ELISAs have limited sensitivity. We evaluated ELISAs using full\u2010length recombinant BP180 and a native BP180\u2010\u03b16\u03b24 integrin complex in six patients with suspected oral or ocular MMP. The conventional NC16A ELISA was negative in four of six patients, and biopsy alone was often insufficient. Both assays provided useful serological support in a subset of cases when interpreted alongside direct immunofluorescence (DIF) and clinical phenotype, whereas in others DIF remained the primary basis for diagnosis. These assays can therefore complement, but not replace, clinicopathological assessment in suspected MMP.<\/jats:p>","DOI":"10.1111\/1346-8138.70529","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:25:42Z","timestamp":1791854742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Utility of Full\u2010Length\n                    <scp>BP180<\/scp>\n                    and Native\n                    <scp>BP180<\/scp>\n                    \u2010\u03b16\u03b24 Integrin Complex\n                    <scp>ELISAs<\/scp>\n                    in Serologically Inconclusive Mucous Membrane Pemphigoid"],"prefix":"10.1111","author":[{"given":"Yukiko","family":"Ishizuka","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-2282","authenticated-orcid":false,"given":"Toshiya","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Enoki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Takahashi\u2010Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai 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