{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:37:31Z","timestamp":1792723051339,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["26"],"award-info":[{"award-number":["26"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CTSC<\/jats:italic>\n                    \u2010syndromic epidermal differentiation disorder is a rare autosomal recessive genodermatosis caused by loss\u2010of\u2010function mutations in the cathepsin C gene. It is characterized by palmoplantar keratoderma and early\u2010onset periodontal destruction, and no standardized disease\u2010specific therapy has been established. We report a 3\u2010year\u2010old boy with disease onset in infancy, presenting with palmoplantar and generalized erythematous scaly lesions, severe pruritus, sleep disturbance, and nail roughness. Whole\u2010exome sequencing followed by Sanger sequencing identified compound heterozygous variants in the cathepsin C gene: c.774C&gt;G inherited from his father and c.328G&gt;T inherited from his mother. Treatment with cyclosporine combined with systemic retinoids failed to prevent disease progression. After pretreatment evaluation and written informed consent from his guardian, secukinumab was administered subcutaneously at a dose of 75\u2009mg at weeks 0, 1, 2, 3, and 4, followed by once every 4\u2009weeks thereafter. After 12\u2009weeks of treatment, the patient showed marked improvement in clinical manifestations, quality\u2010of\u2010life scores, and disease severity scores, with no infectious complications during treatment at our institution. After secukinumab was continued locally, an infection involving the right foot and ankle led to treatment discontinuation, and a pulmonary infection was reported during later follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.70546","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:40:06Z","timestamp":1792719606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secukinumab for Refractory Psoriasiform Cutaneous Manifestations in\n                    <i>CTSC<\/i>\n                    \u2010Syndromic Epidermal Differentiation Disorder: A Pediatric Case Report"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6995-4685","authenticated-orcid":false,"given":"Ke","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Jie","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4932-0826","authenticated-orcid":false,"given":"Meng\u2010Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3500-0855","authenticated-orcid":false,"given":"Jian\u2010Guo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-8295","authenticated-orcid":false,"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-9843","authenticated-orcid":false,"given":"Jian\u2010Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, People's Hospital of Henan University, Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jmg.37.2.88","article-title":"Haim\u2010Munk Syndrome and Papillon\u2010Lef\u00e8vre Syndrome Are Allelic Mutations in Cathepsin C","volume":"37","author":"Hart T. 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