{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:13:09Z","timestamp":1700550789219},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>The spleen is the main organ for immune defense during infection with <jats:italic>Plasmodium<\/jats:italic> parasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model of <jats:italic>Plasmodium yoelii<\/jats:italic> infection, MHC class II<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup> non\u2010T, non\u2010B cells in the spleen were characterized. Although the proportion of conventional dendritic cells was reduced, that of MHC II<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup> non\u2010T, non\u2010B cells increased during the course of infection. The increase in this subpopulation was dependent on the presence of lymphocytes. Experiments using Rag\u20102<jats:sup>\u2212\/\u2212<\/jats:sup> mice with adoptively transferred normal spleen cells indicated that these cells were non\u2010lymphoid cells; however, their accumulation in the spleen during infection with <jats:italic>P. yoelii<\/jats:italic> depended on lymphocytes. Functionally, these MHC II<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup> non\u2010T, non\u2010B cells were able to produce the proinflammatory cytokines alpha tumor necrosis factor and interleukin\u20106 in response to infected red blood cells, but had only a limited ability to activate antigen\u2010specific CD4<jats:sup>+<\/jats:sup> T cells. This study revealed a novel interaction between MHC II<jats:sup>+<\/jats:sup>CD11c<jats:sup>\u2212<\/jats:sup> non\u2010lymphoid cells and lymphoid cells in the accumulations of these non\u2010lymphoid cells in the spleen during infection with <jats:italic>P. yoelii<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12024","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T11:05:49Z","timestamp":1356692749000},"page":"213-223","source":"Crossref","is-referenced-by-count":0,"title":["Accumulation of major histocompatibility complex class II<sup>+<\/sup>CD11c<sup>\u2212<\/sup> non\u2010lymphoid cells in the spleen during infection with <i>Plasmodium yoelii<\/i> is lymphocyte\u2010dependent"],"prefix":"10.1111","volume":"57","author":[{"given":"Rika","family":"Kamei","sequence":"first","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mana","family":"Miyakoda","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"},{"name":"Global COE Program Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiri","family":"Honma","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Yui","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"},{"name":"Global COE Program Nagasaki University 1\u201012\u20104, Sakamoto, Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115638"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06175"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178331"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00876.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00171-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00113-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1988"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/21900"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021072"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.5921"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1300"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.716"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052450"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.11.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.6.2017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.317"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2518"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90029-C"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1998.00709.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.441"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1420"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1352"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.4.557"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217489"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3260"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902528"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040840"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1348-0421.12024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T23:49:12Z","timestamp":1700524152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/1348-0421.12024"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12024","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}