{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T09:06:48Z","timestamp":1723367208567},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,13]],"date-time":"2013-10-13T00:00:00Z","timestamp":1381622400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>The varicella\u2013zoster virus (VZV) Oka vaccine strain (vOka) is a highly immunogenic and safe live vaccine that has long been used worldwide. Because its genome is large, making it suitable for inserting foreign genes, vOka is considered a candidate vector for novel polyvalent vaccines. Previously, a recombinant vOka, rvOka\u2010HN, that expresses mumps virus (MuV) hemagglutinin\u2010neuraminidase (HN) was generated by the present team. rvOka\u2010HN induces production of neutralizing antibodies against MuV in guinea pigs. MuV also expresses fusion (F) protein, which is important for inducing neutralizing antibodies, in its viral envelope. To induce a more robust immune response against MuV than that obtained with rvOka\u2010HN, here an rvOka expressing both HN and F (rvOka\u2010HN\u2010F) was generated. However, co\u2010expression of HN and F caused the infected cells to form syncytia, which reduced virus titers. To reduce the amount of cell fusion, an rvOka expressing HN and a mutant F, F(S195Y) were generated. Almost no syncytia formed among the rvOka\u2010HN\u2010F(S195Y)\u2010infected cells and the growth of rvOka\u2010HN\u2010F(S195Y) was similar to that of the original vOka clone. Moreover, replacement of serine 195 with tyrosine had no effect on the immunogenicity of F in mice and guinea pigs. Although obvious augmentation of neutralizing antibody production was not observed after adding F protein to vOka\u2010HN, the anti\u2010F antibodies did have neutralizing activity. These data suggest that F protein contributes to induction of immune protection against MuV. Therefore this recombinant virus is a promising candidate vaccine for polyvalent protection against both VZV and MuV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12087","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T16:52:03Z","timestamp":1375375923000},"page":"704-714","source":"Crossref","is-referenced-by-count":8,"title":["Novel polyvalent live vaccine against varicella\u2013zoster and mumps virus infections"],"prefix":"10.1111","volume":"57","author":[{"given":"Masaaki","family":"Matsuura","sequence":"first","affiliation":[{"name":"Laboratory of Virology and Vaccinology National Institute of Biomedical Innovation 7\u20106\u20108, Saito\u2010Asagi Ibaraki Osaka 567\u20100085"},{"name":"Kanonji Institute Research Foundation for Microbial Diseases of Osaka University 2\u20109\u201041, Yahata\u2010cho Kanonji Kagawa 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