{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:28:47Z","timestamp":1785364127296,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Interferon\u2010gamma (IFN\u2010\u03b3) is a pro\u2010inflammatory cytokine that plays a pivotal role in the defense mechanism against Brucella infection. It was hypothesized that the IFN\u2010\u03b3 in (+874 A\/T in intron 1) TT and +5644 T\/A, TT genotypes, which are reportedly associated with high IFN production, are associated with susceptibility to brucellosis in Iranian subjects. Genotyping of these IFN\u2010\u03b3 variants by an allele\u2010specific polymerase chain reaction method was performed in 281 subjects, comprising 153 patients with active brucellosis and 128 healthy controls. It was found that the +874 minor allele (A) and homozygote genotype (AA) were significantly more frequently present in brucellosis patients than in controls (OR\u2009=\u20092.588; 95% CI, 1.313\u20135.104;<jats:italic>P<\/jats:italic>\u2009=\u20090.006 for the AA genotype; OR\u2009=\u20091.575; 95% CI, 1.124\u20132.216;<jats:italic>P<\/jats:italic>\u2009=\u20090.010 for the A allele). However, the allelic and genotypic distribution of the IFN\u2010\u03b3 polymorphism at position UTR5644 A&gt;T did not differ significantly between patients and controls (<jats:italic>P\u2009<\/jats:italic>&gt;\u20090.05). The distribution of haplotypes in this study suggests that the T\/A haplotype (+874\/UTR5644), which was present more frequently in controls than in patients, may protect subjects against Brucella infection. It is suggested that IFN\u2010\u03b3 +874 AA genotype and A allele are risk factors for developing brucellosis infection in Iranian subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12093","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T12:58:35Z","timestamp":1377781115000},"page":"785-791","source":"Crossref","is-referenced-by-count":23,"title":["Relationship between \u03b3\u2010interferon gene polymorphisms and susceptibility to brucellosis infection"],"prefix":"10.1111","volume":"57","author":[{"given":"Ebrahim","family":"Eskandari\u2010Nasab","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center"},{"name":"Department of Clinical Biochemistry, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Moghadampour","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Zahedan University of Medical Sciences Khalije Fars Boulevarde Zahedan 14155\u20106455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed\u2010Shahaboddin","family":"Hasani","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Hadadi\u2010fishani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Zahedan University of Medical Sciences Khalije Fars Boulevarde Zahedan 14155\u20106455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed\u2010Ali","family":"Mirghanizadeh\u2010Bafghi","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Sadoughi University of Medical Sciences Hesabi Road Yazd 8915173143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghasem","family":"Asadi\u2010Saghandi","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Sadoughi University of Medical Sciences Hesabi Road Yazd 8915173143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Zare","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Sadoughi University of Medical Sciences Hesabi Road Yazd 8915173143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz","family":"Sadeghi\u2010Kalani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Tehran University of Medical Sciences Enghelab Street Tehran 1352564421 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Ghazali\u2010bina","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Tehran University of Medical Sciences Enghelab Street Tehran 1352564421 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