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In this study, it was found that the Fc receptor \u03b3 chain (FcR\u03b3)\u2010 caspase recruitment domain\u2010containing protein 9 (CARD9)\u2010dependent pathway rather than the myeloid differentiation primary response gene 88 (MyD88)\u2010dependent pathway is involved in the pathogenesis of acute CYP\u2010induced cystitis in mice. Rapid and transient production of interleukin (IL)\u20106 and IL\u20101\u03b2 was detected in the bladder at 4 hr, preceding IL\u201023 and IL\u201017A production and an influx of neutrophils, which reached a peak at 24 hr after injection. As assessed by weight, edema and neutrophil infiltration, cystitis was significantly attenuated in CARD9 knockout (KO) and FcR\u03b3KO mice, this attenuation being accompanied by impaired production of IL\u20101\u03b2, IL\u20106, IL\u201023 and IL\u201017A. The major source of IL\u201017A is the vesical \u03b3\u03b4 T cell population: IL\u201017AKO, C\u03b4KO and Tyk2KO mice showed little IL\u201017A production and reduced neutrophil infiltration in the bladder after CYP injection. These results suggest that FcR\u03b3\u2010CARD9\u2010dependent production of proinflammatory cytokines such as IL\u20101\u03b2, IL\u20106, and IL\u201023 and the subsequent activation of IL\u201017A\u2010producing \u03b3\u03b4 T cells are at least partly involved in the pathogenesis of acute CYP\u2010induced cystitis in mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12100","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:35:55Z","timestamp":1381250155000},"page":"833-841","source":"Crossref","is-referenced-by-count":4,"title":["A C\u2010type lectin receptor pathway is responsible for the pathogenesis of acute cyclophosphamide\u2010induced cystitis in mice"],"prefix":"10.1111","volume":"57","author":[{"given":"Takashi","family":"Dejima","sequence":"first","affiliation":[{"name":"Division of Host Defense, Medical Institute of Bioregulation"},{"name":"Department of Urology, Graduate School of Medical Science Kyushu University 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